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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

25卷

期数:

2019年06期

页码:

634-637

栏目:

临床医学

出版日期:

2019-11-20

文章信息/Info

Title:

To investigate the pathological features of EBV-associated gastric cancer

文章编号:

1006-8147(2019)06-0634-04

作者:

郭玉虹 ;  孙燕;  孙保存

（天津医科大学肿瘤医院病理科，国家肿瘤临床医学研究中心，天津市“肿瘤防治”重点实验室，天津市恶性肿瘤临床医学研究中心，天津300060）

Author(s):

GUO Yu-hong; SUN Yan; SUN Bao-cun

（ Department of Pathology , Cancer Institute and Hospital,Tianjin Medical University, Natinal Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China）

关键词:

胃肿瘤; 病理学; EBV相关性胃癌

Keywords:

gastric neoplasm;  pathology;  EBV-associated gastric cancer

分类号:

R735.2

DOI:

-

文献标志码:

A

摘要:

目的：讨论EBV相关性胃癌（EBVaGC）的病理特征。方法： 回顾44例手术治疗的诊断EBV相关性胃癌病理切片，分析临床病理学特征、免疫组化、原位杂交检测结果，结合相关参考文献进行分析讨论。结果： 44例EBV相关性胃癌患者中男性32例，女性12例，年龄31~85岁。病理特征为肿瘤细胞排列成条索状、巢片状结构，部分可见小的腺腔样结构，间质有大量淋巴样细胞浸润。免疫组化染色显示CKpan肿瘤细胞浆阳性，32例CK8&18肿瘤细胞浆阳性，12例CK7肿瘤细胞浆阳性，12例LCA相应细胞膜阳性，5例Syn和CgA肿瘤细胞浆阳性，原位杂交44例EB病毒早期RNA（EBER）肿瘤细胞核阳性。随访1到5年，40例无瘤存活，3例死亡，1例失访。结论： EBV相关性胃癌具有独特的临床病理学特征，以男性为主，诊断的金标准为EBER-ISH检测，预后较好。

Abstract:

Objective: To investigate the pathological features of EBV-associated gastric cancer(EBVaGC). Methods： A retrospective study was performed on 44 patients with EBV-associated gastric cancer. The clinicopathological features, immunohistochemistry, in situ hybridization results, and related references were analyzed. Results： Of the 44 patients with EBV-associated gastric cancer, 32 were male and 12 were female, aged 31~85 years. The pathological feature is that the tumor cells are arranged in a strip-like shape, a nest-like structure, and some small glandular structures are seen, and a large amount of lymphoid cells infiltrate in the interstitium. Immunohistochemistry showed CKpan(+), 32 cases of CK8&18(+), 12 cases of CK7(+), 12 cases of LCA corresponding (+), 5 cases of Syn and chrome A scattered (+), in situ hybridization of 44 cases of EBER (+). After 1 to 5 years of follow-up, 40 patients survived without tumor, 3 died, and 1 was lost to follow-up. Conclusion：EBV-associated gastric cancer has unique clinicopathological features, especially in male. The gold standard for diagnosis is EBER-ISH, and the prognosis is good.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介 郭玉虹（1980-），女，医师，硕士在读，研究方向：病理学；通信作者：孙保存，E-mail: sunbaocun@aliyun.com。

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更新日期/Last Update: 2020-01-20