|本期目录/Table of Contents|

[1]刘 壮 综 述,吴志强,袁智勇 审 校.Ku70蛋白的翻译后修饰在肿瘤研究中的进展[J].天津医科大学学报,2019,25(04):414-417429.
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Ku70蛋白的翻译后修饰在肿瘤研究中的进展(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25卷
期数:
2019年04期
页码:
414-417429
栏目:
综述
出版日期:
2019-07-20

文章信息/Info

Title:
-
文章编号:
1006-8147(2019)04-0414-04
作者:
刘 壮 综 述; 吴志强; 袁智勇 审 校
（天津医科大学肿瘤医院放疗科，国家肿瘤临床医学研究中心，天津市“肿瘤防治”重点实验室, 天津市恶性肿瘤临床医学研究中心, 天津 300060）
Author(s):
-
关键词:
Ku70; 翻译后修饰; DNA损伤修复; 凋亡
Keywords:
-
分类号:
Q51+R73
DOI:
-
文献标志码:
A
摘要:
Ku70蛋白首次被发现是作为一种细胞核中的DNA损伤修复蛋白，后来被证实它不仅存在于细胞核中执行DNA的损伤修复功能，同时也在细胞质中发挥抗凋亡的作用。Ku70作为一个多功能蛋白，参与多种细胞信号通路，主要包括DNA双链断裂非同源末端连接修复、Bax参与的细胞凋亡、端粒的维持以及DNA复制等。近几年来，Ku70蛋白翻译后修饰在肿瘤研究中取得很大进展。在Ku70蛋白参与的信号通路中，其翻译后修饰作为一个分子开关，控制着其相关功能的发挥。Ku70蛋白的翻译后修饰在肿瘤细胞的增殖、DNA损伤修复和肿瘤细胞凋亡等方面发挥着重要作用。本文就Ku70蛋白的翻译后修饰在肿瘤研究中的进展进行综述。
Abstract:
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参考文献/References:


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备注/Memo

备注/Memo:
基金项目 国家自然科学基金资助项目（81472797）；国家自然基金青年项目（81502660）
作者简介 刘壮（1991-），男，硕士在读，研究方向：肿瘤放射治疗；通信作者：袁智勇, E-mail：zyuan@tmu. edu. cn；吴志强, E-mail：zwu08@ tmu. edu.cn。
更新日期/Last Update: 2019-08-28