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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

25卷

期数:

2019年03期

页码:

246-250

栏目:

临床医学

出版日期:

2019-05-20

文章信息/Info

Title:

The expression and prognostic significance of LCMT1 in hepatocellular carcinoma

文章编号:

1006-8147(2019)03-0246-05

作者:

廖诗晗1; 赵秀兰1; 张艳辉2; 刘铁菊1; 董学易1; 车 娜1; 梁晓辉1; 李逸仙1

（1.天津医科大学基础医学院病理学教研室，天津 300070；2.天津医科大学肿瘤医院病理科，天津 300060）

Author(s):

LIAO Shi-han1;  ZHAO Xiu-lan1;  ZHANG Yan-hui2;  LIU Tie-ju1;  DONG Xue-yi1;  CHE Na1;  LIANG Xiao-hui1;  LI Yi-xian1

（1.Department of Pathology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070China;2.Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, China）

关键词:

LCMT1; GEPIA数据库; MMP2; MAPK3; 肝癌

Keywords:

LCMT1; GEPIA database; MMP2; MAPK3; hepatocellular carcinoma

分类号:

R365

DOI:

-

文献标志码:

A

摘要:

目的：探讨亮氨酸羧基甲基转移酶1（LCMT1）在肝癌中的表达和预后的意义。方法：通过收集网络数据库GEPIA中有关信息进行LCMT1表达情况的分析、相关性分析和生存分析，然后通过免疫组化染色进一步分析LCMT1在肝癌中的表达和预后。结果：LCMT1在肾上腺皮质癌、弥漫性大B细胞淋巴瘤、肝癌和胸腺瘤中的表达和正常组织的表达相比具有统计学意义（P<0.05）。LCMT1在肝癌中高表达，且高表达的患者生存时间短，更容易发生转移。LCMT1和金属蛋白酶2（MMP2）之间的相关系数为0.324（P<0.05）。LCMT1和丝裂原活化蛋白激酶3（MAPK3）存在正相关关系且相关系数为0.76（P<0.05）。结论：LCMT1在肝癌中高表达，且高表达与患者的不良预后有关，LCMT1可能通过激活MAPK3的磷酸化而促进肝癌的发生。

Abstract:

Objective: To investigate the expression and prognostic significance of LCMT1 in hepatocellular carcinoma. Methods: Through collecting relevant information in GEPIA network database, the expression of LCMT1 was analyzed; correlation analysis and survival analysis were carried out. Results: The expression of LCMT1 in adrenal cortical carcinoma, diffuse large B-cell lymphoma, hepatocellular carcinoma and thymoma was significantly higher than that in normal tissues. LCMT1 was highly expressed in hepatocellular carcinoma, and the survival time of patients with high expression of LCMT1 was short, as well as the metastasis. The correlation coefficient between LCMT1 and MMP2 was 0.324. There was a positive correlation between LCMT1 and MAPK3 and the correlation coefficient was 0.76. Conclusion: LCMT1 and MAPK3 are highly expressed in hepatocellular carcinoma, and their high expressions are associated with poor prognosis. LCMT1 is highly expressed in hepatocellular carcinoma and is associated with poor prognosis. LCMT1 may promote the occurrence of hepatocellular carcinoma by activating the phosphorylation of MAPK3.

参考文献/References:

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备注/Memo

备注/Memo:

基金项目 国家自然科学基金面上项目（81572872）
作者简介 廖诗晗（1992-），女，硕士在读，研究方向：病理学；通信作者：赵秀兰，E-mail：xiulanzhao@aliyun.com。

常用功能

更新日期/Last Update: 2019-07-03