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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

24卷

期数:

2018年04期

页码:

315-322

栏目:

出版日期:

2018-07-20

文章信息/Info

Title:

Analysis of prognostic factors for 389 patients with oral squamous cell carcinoma

作者:

张 华; 杨 蓉; 叶贝贝; 张文超

天津医科大学肿瘤医院颌面耳鼻喉肿瘤科，国家肿瘤临床医学研究中心，天津市“肿瘤防治”重点实验室，天津市恶性肿瘤临床医学研究中心，天津 300060

Author(s):

ZHANG Hua; YANG Rong; YE Bei-bei;  ZHANG Wen-chao

Department of Maxillofacial, Ear, Nose and Throat Oncology, Cancer Institute and Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China

关键词:

口腔鳞状细胞癌; 病理; 生存分析; 预后

Keywords:

oral squamous cell carcinoma;  pathology;  survival analysis;  prognosis

分类号:

R739.85

DOI:

-

文献标志码:

Ａ

摘要:

目的：探讨影响口腔鳞状细胞癌（OSCC）患者预后的因素。方法：回顾分析389例初诊OSCC患者的临床病理及随访资料，利用SPSS 20.0及STATA软件行统计学分析。结果：OSCC患者的3年总生存率（OSR）和3年无病生存率（DFSR）分别为74.3%、73.5%，5年OSR和5年DFSR分别为52.7%、44.5%。单因素分析表明，cN分期、pN分期、临床分期、分化程度、淋巴结结外侵犯（ENE）与OSCC预后显著相关（P＜0.05）。COX回归分析显示，临床分期、淋巴结结外侵犯是独立预后影响因素（P＜0.05）。χ2检验表明，临床分期、pN分期、淋巴结结外侵犯与复发密切相关。结论：OSCC 5年生存率相对较低。中晚期患者淋巴结结外侵犯明显，严重影响预后。早期发现和诊治可降低OSCC复发率，从而提高患者生存率。

Abstract:

Objective: To investigate the prognostic factors for oral squamous cell carcinoma (OSCC) patients. Methods: Clinicopathological data and follow-up data of 389 OSCC patients newly diagnosed with OSCC were retrospectively analyzed. SPSS 20.0 and STATA software were used for statistical analysis. Results: The 3-year overall survival rate (OSR) and 3-year disease-free survival rate (DFSR) for OSCC patients were 74.3% and 73.5%, respectively. The 5-year OSR and 5-year DFSR for OSCC patients were 52.7% and 44.5%, respectively. The univariate analysis showed that cN stage, pN stage, clinical stage, differentiated degree, and extranodal extension（ENE） were significantly associated with prognosis（P＜0.05）. COX regression analysis revealed that clinical stage and ENE were the independent prognostic factors（P＜0.05）. Chi-square test demonstrated that clinical stage, pN stage, and ENE were closely related to recurrence. Conclusion: The 5-year survival rate of OSCC was relatively low. ENE was marked in advanced OSCC patients, which seriously could affect the prognosis. Early detection and treatment could reduce the recurrence rate of OSCC, thus improving the survival rate for OSCC patients.

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备注/Memo

备注/Memo:

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更新日期/Last Update: 2018-07-20