|本期目录/Table of Contents|

[1]郭嘉露,李心乐,李新,等.机械加载对高血压大鼠心血管及肾脏损伤的疗效观察[J].天津医科大学学报,2018,24(02):106-111.
　GUO Jia-lu,LI Xin-le,LI Xin,et al.Effect of mechanical loading on the angiocarpy and kidney damage in hypertensive rats[J].Journal of Tianjin Medical University,2018,24(02):106-111.
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机械加载对高血压大鼠心血管及肾脏损伤的疗效观察(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
24卷
期数:
2018年02期
页码:
106-111
栏目:
出版日期:
2018-03-20

文章信息/Info

Title:
Effect of mechanical loading on the angiocarpy and kidney damage in hypertensive rats
作者:
郭嘉露1; 李心乐1; 2; 李新1; 吕子成1; 张玮1; 刘大全1; 2; 张平1; 2
1.天津医科大学人体解剖与组织胚胎学系，天津300070；2.泰达国际心血管病医院再生医学中心，天津 300457
Author(s):
GUO Jia-lu1;  LI Xin-le1; 2;  LI Xin1;  L?譈 Zi-cheng1;  ZHANG Wei1;  LIU Da-quan1; 2;  ZHANG Ping1; 2
1.Department of Anatomy and Histology, Tianjin Medical University, Tianjin 300070, China; 2.Centre for Regenerative Medicine, TEDA International Cardiovascular Hospital, Tianjin 300457, China
关键词:
机械加载; 高盐高脂; 高血压; 血管; 心脏; 肾脏; 大鼠
Keywords:
mechanical loading;  high-sodiumt and high-fat;  hypertension;  vessel;  heart;  kidney;  rats
分类号:
R544.1
DOI:
-
文献标志码:
A
摘要:
目的：探究机械加载对高盐高脂诱导的高血压大鼠的血压及血管、心脏和肾脏的影响。方法：采用高盐高脂饮食方法，建立高血压大鼠模型，给予机械加载治疗。检测治疗后大鼠体质量、体脂含量、BMI、血压值，HE染色观察血管、心脏和肾脏损伤程度。结果：机械加载治疗后高盐高脂大鼠的收缩压、舒张压和平均尾动脉压显著低于造模组，胸主动脉血管壁面积、血管壁厚度、血管壁/血管腔比值、心室指数、心室壁厚度、心肌细胞面积和肾间质炎性细胞数含量较造模组均显著降低。结论：机械加载可以降低高盐高脂高血压大鼠的血压，同时可以改善高血压导致的血管、心脏和肾脏损伤。
Abstract:
Objective: To investigate the effects of mechanical loading on high blood pressure, as well as the injury of blood vessels, heart and kidney of hypertensive rats,which induced by high-sodium and high-fat. Methods: Hypertensive rats were prepared by fed with high-salt and high-fat diet. After mechanical loading, the body weight, body fat content, BMI and blood pressure were measured. The injury and loading effect of blood vessels, heart and kidney were evaluated by HE staining. Results: The blood pressure of loading group was significantly lower than that of the high-sodium and high-fat group. The I-M (intima-mesolamella) cross sectional area, I-MT(intima-mesolamella thickness), I-MT/lumen diameter, HW(mg)/tibia length(mm)(heart weight/tibia length), ventricular wall thickness, cardiomyocyte area and renal interstitial inflammatory cells were significantly decreased after mechanical loading. Conclusion: Mechanical loading could reduce high blood pressure and improve the damage of blood vessels, hearts and kidneys caused by high-sodium and high-fat hypertension.

参考文献/References:

[1] Lewington S, Lacey B, Clarke R, et al. The burden of hypertension and associated risk for cardiovascular mortality in China[J]. JAMA Intern Med, 2016, 176(4): 524
[2] Zhang Y, Yu X J, Chen W S, et al. Exercise training attenuates renovascular hypertension partly via RAS- ROS-glutamate pathway in the hypothalamic paraventricular nucleus[J]. Sci Rep, 2016, 6: 37467
[3] Kumral Z N, Sener G, Ozgur S, et al. Regular exercise alleviates renovascular hypertension-induced cardiac/endothelial dysfunction and oxidative injury in rats[J]. J Physiol Pharmacol, 2016, 67(1): 45
[4] Pellegrin M, Aubert J F, Bouzourène K, et al.Voluntary exercise stabilizes established angiotensin II-dependent atherosclerosis in mice through systemic anti-inflammatory effects[J]. PLoS One, 2015, 10(11): e0143536
[5] Zhang P, Sun Q, Turner C H, et al. Knee loading accelerates bone healing in mice[J]. J Bone Miner Res, 2007, 22(12): 1979
[6] Zhang P, Malacinski G M, Yokota H. Joint loading modality: its application to bone formation and fracture healing[J]. Br J Sports Med,2008, 42(7): 556
[7] Dobrian A D, Schriver S D, Lynch T, et al. Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity[J]. Am J Physiol Renal Physiol, 2003, 285(4): F619
[8] Zhang P, Yokota H. Knee loading stimulates healing of mouse bone wounds in a femur neck[J]. Bone, 2011, 49(4): 867
[9] Li X, Yang J, Liu D, et al. Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis[J]. Sci Rep, 2016, 6: 24668
[10] Boffa J J, Lu Y, Placier S, et al. Regression of renal vascular and glomerular fibrosis: role of angiotensin II receptor antagonism and matrix metalloproteinases[J]. J Am Soc Nephrol, 2003, 14(5): 1132
[11] 于海利, 刘长江, 王一帆, 等. 决明子蒽醌苷对两肾一夹高血压大鼠降压及肾损伤保护作用研究[J]. 临床和实验医学杂志,2014, 13(09): 692
[12] Kadowaki S, Shishido T, Sasaki T, et al. Deficiency of senescence marker protein 30 exacerbates cardiac injury after ischemia/reperfusion[J]. Int J Mol Sci, 2016, 17(4): 542
[13] Rabkin S W. Considerations in understanding the coronary blood flow-leftventricular mass relationship in patients with hypertension[J]. Curr Cardiol Rev, 2017, 13(1): 75
[14] Tfd S, Souza A A, Lima F F, et al. Effect of the exercise of walkers performed in public squares with spontaneous or prescribed intensity on post-exercise hypotension[J]. Rev Saude Publica, 2017, 51: 71
[15] Wong A, Alvarez-Alvarado S, Jaime S J, et al. Combined whole-body vibration training and l-citrulline supplementation improves pressure wave reflection in obese postmenopausal women[J]. Appl Physiol Nutr Metab, 2016, 41(3): 292
[16] Wong A, Alvarez-Alvarado S, Kinsey A W, et al. Whole-body vibration exercise therapy improves cardiac autonomic function and blood pressure in obese pre- and stage 1 hypertensive postmenopausal women[J]. J Altern Complement Med, 2016, 22(12): 970
[17] Zhang P, Turner C H, Yokota H. Joint loading-driven bone formation and signaling pathways predicted from genome-wide expression profiles[J]. Bone, 2009, 44(5): 989
[18] Zhang P, Yokota H. Elbow loading promotes longitudinal bone growth of the ulna and the humerus[J]. J Bone Miner Metab, 2012, 30(1): 31
[19] Liu D, Li X, Li J, et al. Knee loading protects against osteonecrosis of the femoral head by enhancing vessel remodeling and bone healing[J]. Bone, 2015, 81: 620
[20] 巫洪坤,梁贵友.间充质干细胞治疗心血管疾病的研究进展[J].医学综述,2015, 21(14):2538
[21] Wang S, Li Y, Zhao J, et al. Mesenchymal stem cells ameliorate podocyte injury and proteinuria in a type 1 diabetic nephropathy rat model[J]. Biol Blood Marrow Transplant, 2013, 19(4): 538

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备注/Memo

备注/Memo:
文章编号 １００６－８１４７（２０18）０2-0106-06
基金项目 国家自然科学基金资助项目（81572100，81772405， 81601863）；天津滨海新区卫生计生委科技资助项目（2016BWKL002， 2016BWKZ005）
作者简介 郭嘉露（1991-），女，硕士在读，研究方向：从事机械加载与心血管疾病的研究；通信作者：张平，E-mail：pizhang2008@163.com。
更新日期/Last Update: 2018-03-20