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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

23卷

期数:

2017年06期

页码:

562-566

栏目:

技术与方法

出版日期:

2017-11-20

文章信息/Info

Title:

Preparation of HMSN by template method and study of drug loading release properties

文章编号:

1006-8147(2017)06-0562-05

作者:

佟若菲¹; 2; 张 囡²; 李维超²; 房志仲³

 

（1.天津医科大学研究生院，天津300070；2，天津市儿童医院药剂科，天津300074；3.天津医科大学药学院，天津市临床药物关键技术重点实验室，天津 300070）

Author(s):

TONG Ruo-fei¹; 2;  ZHANG-Nan²;  LI Wei-chao²;  FANG Zhi-zhong³

(1.Graduate School,Tianjin Medical University,Tianjin 300070,China;2. Department of Pharmacy, Tianjin Children′s Hospital,Tianjin 300074,China;3.College of Pharmacy, Tianjin Medical University, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics)，Tianjin 300070，China)

关键词:

中空介孔硅球; 自模板法; 表征; 载药释药

Keywords:

HMSN; template method; characterization ; drug loading and release

分类号:

R94

DOI:

-

文献标志码:

A

摘要:

目的: 采用自模板法合成中空介孔硅球（HMSNs），并对其载药释药性能进行研究。方法： 采用自模板法，通过控制反应物摩尔数、温度、时间等反应条件制备HMSNs，并进行载药研究，计算载药率、包封率与释药率。结果：合成的HMSNs球形度良好，具有典型的介孔分子筛特征及硅基骨架特征峰，可以进行结构确证，药物在42 h的累积释药百分数达70%以上。结论：HMSNs可用于抗癌药物伊马替尼的装载，达到缓释的目的。

Abstract:

Objective : To use the template method to synthesize mesoporous silica hollow ball (HMSNs), to explore the drug loading and release properties. Methods: The self-template method was used to prepare HMSNs by controlling the molar ratio, temperature and time of reactants, and the drug loading rate, encapsulation efficiency and drug release rate were calculated. Results: The synthesized HMSNs had good sphericity, typical mesoporous molecular sieve and the characteristic peak of the silicon skeleton. The structure was confirmed , and the drug release rate reached more than 70% in 42 hours. Conclusion: The utility model can be used for the loading of anticancer drug imatinib.

参考文献/References:

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相似文献/References:

备注/Memo

备注/Memo:

作者简介 佟若菲（1977-），女，副主任药师，硕士在读，研究方向：临床药学；通信作者：房志仲，E-mail:fangzhizhong@tijmu.edu.cn。

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更新日期/Last Update: 2017-11-14