|本期目录/Table of Contents|

[1]李菲,李自军.血清b-crosslaps、Cathe K水平变化在骨质疏松症诊断中的应用价值[J].天津医科大学学报,2017,23(06):534-536.
　LI Fei,LI Zi-jun.Application value of serum b -crosslaps, Cathe K level in diagnosis of osteoporosis[J].Journal of Tianjin Medical University,2017,23(06):534-536.
点击复制

血清b-crosslaps、Cathe K水平变化在骨质疏松症诊断中的应用价值(PDF)
分享到：

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
23卷
期数:
2017年06期
页码:
534-536
栏目:
临床医学
出版日期:
2017-11-20

文章信息/Info

Title:
Application value of serum b -crosslaps, Cathe K level in diagnosis of osteoporosis
文章编号:
1006-8147(2017)06-0534-03
作者:
李菲; 李自军
（郑州市骨科医院检验科，郑州 450052）
Author(s):
LI Fei;  LI Zi-jun
（Department of Clinical Laboratory , Orthopedics Hospital of Zhengzhou, Zhengzhou 450052, China）
关键词:
b-胶原降解产物; 组织蛋白酶K; 骨质疏松症; 应用价值
Keywords:
b- collagen degradation products;  cathepsin K;  osteoporosis;  application value

分类号:
R681
DOI:
-
文献标志码:
A
摘要:
目的 ：探讨b-胶原降解产物（b-crosslaps）、血清组织蛋白酶K（Cathe K）在骨质疏松诊断中的应用价值。方法：选取接受骨密度检测的受试者289例，其中骨量正常者76例（骨量正常组），骨量减少者91例（骨量减少组），骨质疏松者122例（骨质疏松组），检测受试者b-crosslaps、Cathe K及骨密度（BMD）。结果：骨质疏松组b-crosslaps和Cathe K分别为（0.97±0.14）ng/mL和（35.22±9.76）ng/L，明显高于骨量正常组和骨量减少组（P＜0.05）；骨质疏松组BMD明显低于骨量减少组和骨量正常组（P＜0.05），骨量减少组BMD低于骨量正常组（P＜0.05）；骨量正常组和骨量减少组b-crosslaps和Cathe K比较差异无统计学意义（P＞0.05）；b-crosslaps、Cathe K和BMD呈负相关（r=-0.344和-0.301，P＜0.05），而b-crosslaps和Cathe K之间无相关性（P＞0.05）。结论：血清b-crosslaps、Cathe K在骨质疏松诊断中有一定的价值，其水平与骨密度有相关性。
Abstract:
Objective:To investigate the application value of b collagen degradation products (b-crosslaps), serum cathepsin K (Cathe K) in the diagnosis of osteoporosis. Methods: We selected 289 patients who accepted bone mineral density test i, among them, 76 cases of normal bone mass (normal bone mass group), 91 cases of bone mass reduction (bone mass reduction group), 122 cases of osteoporosis (osteoporosis group), detected subjects b-crosslaps, Cathe K and bone mineral density (BMD). Results:Osteoporosis group b-crosslaps and Cathe K were (0.97 ± 0.14) ng/mL and (35.22 ± 9.76) ng/L, significantly higher than the normal bone mass group and osteopenia group (P < 0.05);The BMD in the osteoporosis group was significantly lower than that in the bone mass reduction group and the normal bone mass group (P < 0.05). The bone mass reduction group BMD was lower than the normal group (P< 0.05);The normal bone mass group and bone mass reduction group b-crosslaps and Cathe K had no significant differences (P>0.05);b-crosslaps, Cathe was negatively correlated withBMD (r=-0.344 and -0.301, P< 0.05), but no correlation between b-crosslaps and Cathe K (P> 0.05). Conclusion:Serum b-crosslaps, Cathe K has certain value in the diagnosis of osteoporosis, and its levels are correlated with bone mineral density.

参考文献/References:

[1] Inage K, Orita S, Yamauchi K, et al. Erratum: correction of figures. The time course changes in bone metabolic markers after administering the anti-receptor activator of nuclear factor-kappa B ligand antibody and drug compliance among patients with osteoporosis[J]. Asian Spine J,2015,9(6):999-1002.

[2] Liang D, Ren H, Qiu T, et al. Extracts from plastrum testudinis reverse glucocorticoid-induced spinal osteoporosis of rats via targeting osteoblastic and osteoclastic markers[J]. Biomed Pharmacother ,2016,82:151-160.

[3] 史晓林，梁博程，姚建亮，等. 基于TMT标记联合LC-ESI-MS/MS技术筛选绝经后骨质疏松症的血清分子标志物研究[J]. 中华骨科杂志, 2015,35(10):1004

[4] 李新萍，李晓玉，范斌，等. 老年患者椎体脆性压缩性骨折、爆裂性骨折、多发性骨折骨转换生化标志物的早期变化[J]. 中国老年学杂志, 2016,25(12):3000

[5] 楼慧玲，彭程，陈巧聪. 三种骨代谢标志物的测定在老年骨质疏松症患者髋部脆性骨折中的临床价值[J]. 南方医科大学学报, 2012,22(09):1346

[6] 及金宝，林兴喜，朱翔蓉，等. 骨代谢标志物对社区绝经后骨质疏松症患者发生髋部骨质疏松及骨折的评估作用[J]. 中国全科医学, 2016,32(14):1625

[7] 范光磊，薄静莉，陈杰敏，等. 骨转换生化标志物与老年2型糖尿病患者并发骨质疏松的相关性研究[J]. 中华老年医学杂志,2012,31(8):657

[8] Cho S W. New biological markers of bone metabolism in osteoporosis treatment[J]. Endocrinol Metab , 2016,31(3):400

[9] Sánchez A, Brun L R, Salerni H, et al. Effect of denosumab on bone mineral density and markers of bone turnover among postmenopausal women with osteoporosis[J]. J Osteoporos ,2016, 2016:8738959

[10] 赵和平. P1N P、β-Crosslaps与绝经老年女性骨质疏松相关性研究[J]. 陕西医学杂志,2014,25(7):865

[11] 刘菊，梅群超，罗娜，等. 老年女性骨质疏松症患者血清骨标志物和E_2含量的变化及临床意义[J]. 实用老年医学,2012,32(06):470

[12] 田广，陈雪萍，康朝胜. 3~6岁儿童血浆β-胶原特殊序列和N端中段骨钙素变化规律探讨[J]. 中国骨质疏松杂志,2015,22(01):25

[13] 帕力达·阿不力孜，艾克拜·艾合麦提，周晓辉，等. 新疆老年男性骨转化生化标志物及性激素与骨质疏松症的相关性研究[J]. 中国骨质疏松杂志,2016,25(10):1241

[14] 李国新，袁忠治，温健，等. 椎体骨质疏松骨折患者骨转换生化标志物的临床研究[J]. 中国骨质疏松杂志,2015,32(11):1357

[15] 施鸣，范璐，陈新. 骨代谢标志物与骨质疏松的相关性研究[J]. 标记免疫分析与临床,2012,25(06):351

相似文献/References:

[1]聂海丹,王瑛慧,刘娟,等.可口可乐和汇源橙汁及其所含饮料酸对组织蛋白酶K活性的影响[J].天津医科大学学报,2020,26(05):462.
　NIE Hai-dan,WANG Ying-hui,LIU Juan,et al.The effects of Coca-Cola, Huiyuan orange juice and the acid contents of the two beverages on the activity of cathepsin K[J].Journal of Tianjin Medical University,2020,26(06):462.

备注/Memo

备注/Memo:
基金项目河南省科技局项目基金资助（153PKJGG084）

作者简介? 李菲（1978-），女，主管检验技师,本科，研究方向:临床检验; E—mail：ab561238985@163.com。

更新日期/Last Update: 2017-11-14