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[1]陈海燕 综述,姜埃利 审校.急性肾损伤的生物标志物——血红素加氧酶1[J].天津医科大学学报,2017,23(05):483-封3.
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急性肾损伤的生物标志物——血红素加氧酶1(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
23卷
期数:
2017年05期
页码:
483-封3
栏目:
综述
出版日期:
2017-09-20

文章信息/Info

Title:
-
文章编号:
1006-8147(2017)05-0483-03
作者:
陈海燕 综述; 姜埃利 审校
（天津医科大学第二医院肾脏病血液净化科，天津300211）
Author(s):
-
关键词:
急性肾损伤; 血红素加氧酶1; 肾功能衰竭; 细胞保护作用; 氧化应激
Keywords:
-
分类号:
R692.5
DOI:
-
文献标志码:
A
摘要:
急性肾损伤（?AKI）是临床常见疾病，特别是危重病人，其发病率和死亡率均较高。AKI的病理生理过程复杂，涉及多种途径，包括炎症、细胞的自噬、细胞周期的变化和氧化应激等。最近的证据表明对肾脏的单一严重损伤可导致慢性肾脏病的发生，因此，必须及时有效的治疗AKI。在这篇综述中，有证据表明血红素加氧酶1（heme oxygenase 1，HO-1）在动物AKI模型中的保护效应。HO-1调节氧化应激、细胞自噬和炎症，并通过直接和间接机制调节细胞周期的进程。
Abstract:
-

参考文献/References:

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备注/Memo

备注/Memo:
作者简介 陈海燕（1977-），女，主治医师，博士，研究方向：慢性肾脏病及其并发症的诊治；通信作者：姜埃利，E-mail:carlos_j@126.com。
更新日期/Last Update: 2017-09-21