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[1]陈可新,郝晓东,薄志强,等.≤pT2N0M0膀胱癌根治术后近期复发的影响因素分析[J].天津医科大学学报,2017,23(04):357-360.
　CHEN Ke-xin,HAO Xiao-dong,BO Zhi-qiang,et al.Influencing factors and prognosis of short-term relapse after radical cystectomy of primary bladder cancer（≤pT2N0M0）[J].Journal of Tianjin Medical University,2017,23(04):357-360.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
23卷
期数:
2017年04期
页码:
357-360
栏目:
临床医学
出版日期:
2017-07-02

文章信息/Info

Title:
Influencing factors and prognosis of short-term relapse after radical cystectomy of primary bladder cancer（≤pT2N0M0）
文章编号:
1006-8147(2017)04-0357-04
作者:
陈可新; 郝晓东; 薄志强; 刘 豫; 杜 娥; 张志宏
（天津医科大学第二医院泌尿外科，天津市泌尿外科研究所，天津300211）

Author(s):
CHEN Ke-xin;  HAO Xiao-dong;  BO Zhi-qiang;  LIU Yu;  DU E;  ZHANG Zhi-hong
（Department of Urology，The Second Hospital， Tianjin Medical University， Tianjin Institute of Urology，Tianjin 300211，China）
关键词:
膀胱癌; 膀胱癌根治术; 近期复发; 危险因素
Keywords:
bladder cancer; radical cystectomy; short-term recurrence; risk factors
分类号:
R737.14
DOI:
-
文献标志码:
A
摘要:
?目的 ：探讨膀胱癌（≤pT2N0M0）根治术（RC）后患者肿瘤近期复发的影响因素。方法 ：回顾性分析173例行RC患者的临床资料，?将RC术后患者分为两组：≤6月复发为近期复发，＞6月为非近期复发。分析肿瘤部位、肿瘤单发或多发、肿瘤直径、肿瘤分期、分级、切断尿道的方式、术中输血等因素与术后肿瘤近期复发的关系。结果 ： 173例患者中63例（36.4%）出现肿瘤复发，其中近期复发19例(10.9%)，非近期复发44例（25.4%）。性别、肿瘤数量、离断尿道方式、术中淋巴清扫术、后尿道肿瘤侵犯为近期复发的影响因素（χ2=4.02,4.73,7.15,4.47,5.42，P＜0.05），其中性别、离断尿道方式、肿瘤侵犯后尿道为近期肿瘤复发的独立危险因素（RR=0.124、7.154、5.415,P＜0.05）。结论：性别、离断尿道方式、肿瘤侵犯后尿道为RC术后近期复发的独立危险因素。
Abstract:
Objective：To investigate the influencing factors and prognosis of short-term recurrence after radical cystectormy (RC) of primary bladder cancer(≤pT2N0M0). Methods: Clinical data of 173 patients who received radical cystectormy were analyzed. Some patients with early clinical pathological diagnosis， had no lymph node disease (≤pT2N0M0). Tumor recurrence occurred within 6 months after operation was defined as short-term recurrence. Relationship between postoperative tumor recurrence and the tumor site, tumor number, tumor diameter, tumor staging, grading, the way of mutilating urethra， intraoperative blood transfusion and so on were analyzed. Results: In 173 patients, 63 cases (36.4%) were found tumor recurrence, including 19 cases (10.9%) with in short-term recurrence and non short-term recurrence in 44 cases (25.4%). Sex, tumor number, mutilating urethra without occlusion, lymph node dissection, posterior urethra invasion were influencing factors for short-term recurrence (χ2=4.02,4.73,7.15,4.47,5.42，P＜0.05＝, sex, posterior urethra invasion, mutilating urethra without occlusion as independent risk factors for recent tumor recurrence (RR=0.124、7.154、5.415,P＜0.05. Conclusion： Sex, the way of mutilating urethra, and the tumor invasion of the urethra are independent risk factors for short-term tumor recurrence. There is a significant difference in the survival rates between patients with short-term and non-short-term tumor recurrence.

参考文献/References:

[1] Jemal A, Bray F, Center M M, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011,61(2):69

[2] Lund L, Jacobsen J, Clark P, et al. Impact of comorbidity on survival of invasive bladder cancer patients, 1996-2007: a Danish population-based cohort study[J]. Urology, 2010,75(2):393

[3] 唐鹏, 张洪典, 于振涛. 食管胃交界部腺癌根治术后早期复发的危险因素及预后分析[J]. 中华医学杂志, 2013,93(45):3594

[4] 赵敬柱, 张汝鹏, 王刚, 等. 进展期胃癌根治术后早期复发的危险因素分析[J]. 中华普通外科杂志, 2011,26(7):549

[5] Olsen L H, Genster H. Prolonging of the follow-up intervals for non-invasive bladder tumors[J]. Ugeskr Laeger, 1998,160(7):1019

[6] Olsen L H, Genster H G. Prolonging follow-up intervals for non-invasive bladder tumors: a randomized controlled trial[J]. Scand J Urol Nephrol Suppl, 1995,172:33

[7] Albisinni S, Rassweiler J, Abbou C, et al. Long-term analysis of oncological outcomes after laparoscopic radical cystectomy in Europe: results from a multicentre study by the European Association of Urology (EAU) section of Uro-technology[J]. BJU International, 2015,115(6):937

[8] Witjes J A, Compérat E, Cowan N C, et al. EAU Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2013 Guidelines[J]. European Urology, 2014,65(4):778

[9] Albisinni S, Fossion L, Oderda M, et al. Critical Analysis of Early Recurrence after Laparoscopic Radical Cystectomy in a Large Cohort by the ESUT[J]. J Urol, 2016,195(6):1710

[10] 蔡荣耀, 黄志勇, 梁宾勇, 等. 原发性肝细胞癌根治术后肿瘤复发的影响因素及预后[J]. 中华消化外科杂志, 2011,10(4):263

[11] 邵淑丽, 柳晓肃. 卵巢上皮性癌的预后影响因素分析[J]. 中华妇产科杂志, 2010,45(2):132

[12] Lumachi F, Mazza F, Del C A, et al. Short-term Survival of Patients with Lung Metastases from Colorectal and Non-colorectal Cancer Who Underwent Pulmonary Metastasectomy[J]. Anticancer Res, 2015,35(6):3563

[13] Puente D, Malats N, Cecchini L, et al. Gender-related differences in clinical and pathological characteristics and therapy of bladder cancer[J]. Eur Urol, 2003,43(1):53

[14] Raimondi C, Gradilone A, Gazzaniga P. Circulating tumor cells in early bladder cancer: insight into micrometastatic disease[J]. Expert Rev Mol Diagn, 2014,14(4):407.

[15] Geldof A A. Models for cancer skeletal metastasis: a reappraisal of Batson’s plexus[J]. Anticancer Res, 1997,17(3A):1535

[16] Batson O V. The function of the vertebral veins and their role in the spread of metastases. 1940[J]. Clin Orthop Relat Res, 1995(312):4

[17] Brook R C, Tung K, Oeppen R. Batson’s plexus and retrograde venous spread of malignancy – a pictorial review[J]. Cancer Imaging the Official Publication of the International Cancer Imaging Society, 2014,14(Suppl 1):1

[18] Pouessel D, Bastuji-Garin S, Houédé N, et al. Adjuvant Chemotherapy After Radical Cystectomy for Urothelial Bladder Cancer: Outcome and Prognostic Factors for Survival in a French Multicenter, Contemporary Cohort[J]. Clinical Genitourinary Cancer, 2016.

[19] 曹明, 赵宏, 穆鑫, 等. 吉西他滨联合顺铂方案新辅助化疗联合全膀胱切除术治疗肌层浸润性膀胱癌的9年回顾性分析[J]. 中华泌尿外科杂志, 2014,35(1):49

[20] Netto G J. Molecular genetics and genomics progress in urothelial bladder cancer[J]. Semin Diagn Pathol, 2013,30(4):313

[21] Wang A X, Chang J W. Prognostic value of multiple-gene joint detection in bladder cancer[J]. Chinese? ?Clin Oncol , 2014,41(18):1190

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备注/Memo

备注/Memo:
基金项目 国家自然科学基金资助项目（81400686）

作者简介 陈可新（1989-），男，硕士在读，研究方向：泌尿外科；

通信作者：张志宏，E-mail：drzhangzhihong@163.com。



更新日期/Last Update: 2017-07-01