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[1]张 燕,何新飙.ICU患者感染鲍曼不动杆菌的危险因素及耐药性分析[J].天津医科大学学报,2016,22(04):318-321.
　ZHANG Yan,HE Xin-biao.Analysis of risk factors and drug resistance of the patients fected with Acinetobater baumanii in intensive care unit[J].Journal of Tianjin Medical University,2016,22(04):318-321.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
22卷
期数:
2016年04期
页码:
318-321
栏目:
临床医学
出版日期:
2016-07-19

文章信息/Info

Title:
Analysis of risk factors and drug resistance of the patients fected with Acinetobater baumanii in intensive care unit
文章编号:
1006-8147（2016）04-0318-04
作者:
张 燕; 何新飙
（天津医科大学第二医院重症监护病房，天津 300211）
Author(s):
ZHANG Yan; HE Xin-biao
（Department of ICU， The Second Hospital ，Tianjin Medical University，Tianjin 300211,China）
关键词:
鲍曼不动杆菌;  医院感染; 耐药性; 危险因素
Keywords:
acinetobater baumanii;  nosocomial infection; ? drug resistance;  risk factor
分类号:
R515
DOI:
-
文献标志码:
A
摘要:
目的：探讨重症监护病房（ICU）鲍氏不动杆菌(AB)医院感染的危险因素和耐药情况。方法：收集2012年ICU住院患者363例，分离培养AB并进行药敏试验。收集所有患者住院信息分析其发生AB的危险因素。结果：鲍曼不动杆菌医院感染患者51例。经多因素Logistic分析，ICU入住时间＞7d、机械通气、深静脉置管、抗生素使用≥3种、激素、糖尿病、白蛋白＜25g/L是ICU患者感染AB的独立危险因素。该院ICU患者感染的鲍氏不动杆菌耐药率高，其中多重耐药鲍氏不动杆菌（MDRAB）占39.2%，广泛耐药鲍氏不动杆菌（XDRAB）占37.3%，全耐药鲍氏不动杆菌（PDRAB）占2%，敏感菌占21.6%。对多粘菌素B、美满霉素、头孢哌酮／舒巴坦敏感性较高，敏感率依次为92.2%、45.1%、58.8%。结论：AB耐药率逐年升高，合理使用抗菌素、缩短有创机械通气时间有助于控制AB的感染。
Abstract:
?Objective: To investigate the risk factors of nosocomial infection caused by Acinetobater baumanii (AB)in intensive care unit（ICU），and to analyze drug resistance of AB strains. Methods: Three hundred and sixty two patients in ICU were enrolled in this study. Hospital information of each patient was collected to analyze latent risk factors. Results: Fifty one cases with nosocominal infection caused by AB were confirmed .Logistic regression analysis showed that the risk factors for infection caused by AB in ICU were duration in ICU of more than 7 days，use of invasive mechanical ventilation，deep vein catheterization，use of antibiotics more than 3 kinds，hormonic autacoid，diabetes mellitus，and albumin less than 25 grams per liter. Drug resistance of AB infected by patients in ICU was high. Multiple drug resistance Acinetobater baumanii（MDRAB） accounted for 39.2%.Extensive drug resistance Acinetobater baumanii (XDRAB)accounted for 37.3%.Pan drug resistance Acinetobater baumanii (PDRAB)accounted for 2%.Sensitive Acinetobater baumanii accounted for 21.6%， and highly sensitive to polymyxin B，minocycline and cefoperazone-sulbactam，sensibility in order were 92.2%，45.1%，58.8% .Conclusion: The drug resistance of Acinetobater baumannii could increase gradually year by year.Appropriate antibiotic administration and reducing the time of invasive mechanical ventilation may essential for Acinetobater baumanii infection.

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备注/Memo

备注/Memo:
基金项目 天津市自然科学基金项目（09JCYBJC11300）

作者简介 张燕（1987-），女，硕士在读，研究方向：急诊医学；通信作者：何新飙，E-mail:hexinbiaoqz@163.com。

更新日期/Last Update: 2016-07-13