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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

22卷

期数:

2016年06期

页码:

483-486

栏目:

基础医学

出版日期:

2016-11-20

文章信息/Info

Title:

Expression and significance of NF-B and eIF4E in endometrial intraepithelial neoplasia and endometrioid carcinoma

文章编号:

1006-8147（2016）06-0483-4

作者:

赵庆庆;  宋文静

(天津医科大学病理学教研室,天津 300070)

Author(s):

ZHAO Qing-qing; SONG Wen-jing

(Department of Pathology, Tianjin Medical University, Tianjin 300070, China)

关键词:

子宫内膜上皮内瘤变; 子宫内膜样癌; NF-κB; eIF4E; 免疫组化

Keywords:

endometrial intraepithelial neoplasia;  endometrioid carcinoma;  NF-B;  eIF4E ;  immunohistochemistry

分类号:

R737.33

DOI:

-

文献标志码:

A

摘要:

目的 ：探讨NF-κB和eIF4E在子宫内膜上皮内瘤变（EIN）和子宫内膜样癌（EC）中的表达规律及意义。 方法：免疫组织化学SP法检测NF-κB和eIF4E在增殖期子宫内膜、子宫内膜增生、EIN及EC中的表达，应用Mann－WhitneyU检验及Wilcoxon检验进行数据统计分析。结果：（1）NF-κB在5组中呈递增性表达，EIN组与EC组间无显著差异性（P＞0. 05），与其余两组组间表达均有统计学意义（P < 0. 05）。（2）eIF4E在EC中的表达明显高于增殖期子宫内膜、子宫内膜增生及EIN，且EIN组与各组间差异有统计学意义（P < 0. 05）。（3）NF-κB和eIF4E在EIN及相关病变中的表达有显著相关性（r = - 0.949，P＜0. 05）。结论：NF-κB和eIF4E在EIN及EC中高表达，在EIN发展为EC的过程中逐渐被激活，进而加速转录、翻译，增大EIN进展为子宫内膜样癌的可能性。

Abstract:

Objective: To investigate the expressions and roles of NF-κB and eIF4E in the endometrial intraepithelial neoplasia(EIN) and endometrioid carcinoma(EC).

Methods：Immunohistochemical SP method was used to detect the expressions of NF-κB and eIF4E in the proliferative stage of endometrium, hyperplasia endometrium, EIN and EC. The statistical data using test were analyzed MannWhitney U test and Wilcoxon. Results: (1) The expression levels of NF-κB increased gradually, and there was no statistically significant difference between EIN and EC(P＞0.05). However, difference between the EIN and other groups was significance.(2)The positive rate of eIF4E was significantly higher in EC than in proliferative stage of endometrium,hyperplasia endometrium and EIN(P < 0.05).(3)NF-κB and eIF4E had a strong correlation between EIN and associated lesions(r = - 0.949,P＜0.05). Conclusion: NF-κB and eIF4E are highly expressed in EIN and EC. They may be gradually activated in the process of EIN development to EC, and then accelerate transcription or translation,and increase the possibility of endometrial carcinoma.

参考文献/References:

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相似文献/References:

[1]宋露露,宋文静.子宫内膜样癌及其前驱病变YAP1、PTEN和eIF4E的表达及意义[J].天津医科大学学报,2017,23(05):412.
　SONG Lu-lu,SONG Wen-jing.Expression and significance of YAP1, PTEN and eIF4E in endometrioid carcinoma and precursor lesions[J].Journal of Tianjin Medical University,2017,23(06):412.

备注/Memo

备注/Memo:

作者简介 赵庆庆（1990-），女，硕士在读，研究方向：女性生殖系统肿瘤；

通信作者：宋文静，E-mail：songwenjing2004@aliyun.com。

常用功能

更新日期/Last Update: 2016-11-25