|本期目录/Table of Contents|

[1]许丹丹,王茹瑶,刘 蕊,等.老年结直肠癌的危险因素及与循环IGF-1水平的相关性研究[J].天津医科大学学报,2016,22(05):424-427.
　XU Dan-dan,WANG Ru-yao,LIU Rui,et al.Research on the risk factors of senile colorectal cancer and the correlation with circulating insulin-like growth factor-1[J].Journal of Tianjin Medical University,2016,22(05):424-427.
点击复制

老年结直肠癌的危险因素及与循环IGF-1水平的相关性研究(PDF)
分享到：

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
22卷
期数:
2016年05期
页码:
424-427
栏目:
临床医学
出版日期:
2016-09-20

文章信息/Info

Title:
Research on the risk factors of senile colorectal cancer and the correlation with circulating insulin-like growth factor-1
文章编号:
1006-8147（2016）05-0424-4
作者:
许丹丹1; 2 ; 王茹瑶1; 2 ; 刘 蕊2 ; 赵立杰2 ; 胡丽玲2 ; 孙 遨2 ; 吴 萍2
（1． 天津医科大学研究生院 ，天津 300070；2 天津市人民医院检验学部， 天津 300121）
Author(s):
XU Dan-dan1; 2;  WANG Ru-yao1; 2;  LIU Rui2;  ZHAO Li-jie2;  HU Li-ling2;  SUN Ao2;  WU Ping2
(1.Graduate School, Tianjin Medical University, Tianjin 300070, China; 2. Department of Laboratory, Tianjin Union Medicine Center, Tianjin 300121, China)
关键词:
结直肠肿瘤; 老年人; 危险因素; 胰岛素样生长因子-1
Keywords:
colorectal neoplasms;  aged;  risk factors;  insulin-like growth factor 1
分类号:
R735.3
DOI:
-
文献标志码:
A
摘要:
目的：探讨老年结直肠癌（CRC）的危险因素及与循环胰岛素样生长因子-1（IGF-1）水平的相关性。方法：选取209例经结肠镜病理确诊的CRC患者为病例组，同期进行健康体检的208例非肿瘤患者为对照组，收集所有研究对象的基本临床资料，采用化学发光免疫分析法检测受检人群的循环IGF-1水平。结果：CRC组吸烟、饮酒、高血压、冠心病史者所占比例高于对照组（P＜0.05），血糖（GLU）、白细胞（WBC）、IGF-1也明显高于对照组，而甘油三酯（TG）明显低于正常对照组（P＜0.05）。多因素二元Logistic回归分析显示，性别、吸烟、高血压、冠心病、GLU＞6.10 mmol/L、WBC＞9.5×109/L以及IGF-1＞194.31 ng/ml是CRC的危险因素，且高水平IGF-1可使CRC发生风险增高（OR=2.77，95%CI：1.02~7.49，P＜0.05）。CRC组循环IGF-1水平在肿瘤长径≥5 cm组高于＜5 cm组，在晚期(Ⅲ～IV)组高于早期（I～Ⅱ）组，低分化组高于高分化和中分化组，伴局部淋巴结转移组高于无局部淋巴结转移组（P＜0.05）。结论：循环IGF-1水平与CRC的进展密切相关，戒烟、低糖低脂饮食在一定程度上可预防CRC的发生。
Abstract:
Objective: To explore the risk factors and the correlation with circulating insulin-like growth factor-1 (IGF-1) in senile colorectal cancer. Methods: Two hundred and nine patients with colorectal cancer in case group and 208 non-cancer patients in control group were included in Tianjin Union Medicine Center. The basic clinical data of all subjects were collected. The serum level of IGF-1 was determined by chemiluminescence technology. Results: The proportion of patients with the history of smoking, alcohol, hypertension and coronary heart disease in CRC group was significantly higher than that of the control group (P<0.05). Blood glucose, white blood cell and circulating IGF-1 level in CRC group were also significantly higher than those of the control group, while triglycerides was lower (P<0.05). According to analysis of covariance, gender, smoking, hypertension, coronary heart disease history, blood glucose higher than 6.10 mmol/L, white blood cell higher than 9.5×109/L and IGF-1 higher than 194.31 ng/mL were risk factors of CRC. The odds ratio (OR) of patients with higher circulating IGF-1 was 2.77-fold of the lower (95%CI:1.02~7.49, P=0.045). Circulating IGF-1 was significantly higher in patients with CRC with the tumor no less than 5 cm or at advanced stages (stages Ill and IV) or with low differentiation or with regional lymphoid node metastasis than in those with the tumor less than 5 cm or at early stages(stages I and II) or with middle and high differentiation or without regional lymphoid node metastasis(P<0.05). Conclusion: Circulating IGF-1 may play an important role in the development of CRC. Keeping away from cigarettes, low-sugar fat diet could reduce the risk of CRC to some extent.

参考文献/References:

[1] International Agency for Research on Cancer. Colorectal cancer estimated incidence, mortality and prevalence worldwide in 2012[EB/OL]. http://globocan.iarc.fr/Pages/fact_sheets_cancer. aspx

[2] 徐涛, 刘福旭, 张颖, 等.老年人与青年人大肠癌的临床对比分析[J].中国老年学杂志, 2007,27(16):1629

[3] 郎森阳.老年期抑郁和痴呆与潜在的神经系统疾病[J].中华老年心脑血管病杂志, 2009,12(11):945

[4] Kilic L, Yildiz I, Sen F K, et al. D-dimer and international normalized ratio (INR) are correlated with tumor markers and disease stage in colorectal cancer patients[J]. Cancer Biomark, 2015,15(4):405

[5] 谢克俭, 陈筱华, 竺海波, 等.前列腺癌患者血清胰岛素样生长因子-1检测的临床意义[J].中华泌尿外科杂志, 2003,24(2):117

[6] 陈万青, 郑荣寿, 曾红梅, 等. 2011年中国恶性肿瘤发病和死亡分析[J].中国肿瘤, 2015,24(1):1

[7] Chen W, Wang S, Tian T, et al.Phenotypes and genotypes of insulin-like growth factor 1, IGF-binding protein-3 and cancer risk: evidence from 96 studies[J]. Eur J Hum Genet, 2009,17(12):1668

[8] Probst-Hensch N M, Yuan J M, Stanczyk F Z, et al.IGF-1, IGF-2 and IGFBP-3 in prediagnostic serum: association with colorectal cancer in a cohort of Chinese men in Shanghai[J]. Br J Cancer, 2001,85(11):1695

[9] Hanson A M, Kittilson J D, Martin L E, et al.Environmental estrogens inhibit growth of rainbow trout (Oncorhynchus mykiss) by modulating the growth hormone-insulin-like growth factor system[J]. Gen Comp Endocrinol, 2014,196:130

[10] 万德森. 我国结直肠癌的流行趋势及对策[J].中华肿瘤杂志，2011,33(7):481

[11] Tiryakioglu O, Kadiolgu p, Canerolgu N U, et al.Age dependency of serum insulin - like growth factor (IGF)-1 in healthy Turkish adolescents and adults[J]. Indian J Med Sci, 2003,57(12):543

[12] 赵红, 汪承亚, 段宇, 等.老年2型糖尿病患者胰岛素治疗后胰岛素样生长因子Ⅰ的变化[J].中华内分泌代谢杂志,2001,17(5):295

[13] Berster J M, Goke B.Type 2 diabetes mellitus as risk factor for colorectal cancer[J].Arch Physiol Biochem,2008,114(1):84

相似文献/References:

[1]李衍训,孙晋津,刘 庚,等.腹腔镜与开腹手术治疗高龄急性胆囊炎患者临床分析[J].天津医科大学学报,2015,21(04):311.
　LI Yan-xun,SUN Jin-jin,LIU Geng,et al. Laparoscopic cholecystectomy versus open cholecystectomy in elderly patients with acute cholecystitis [J].Journal of Tianjin Medical University,2015,21(05):311.
[2]孟昀,张华,于泳浩.右美托咪定对老年腹腔镜手术患者脑氧饱和度及术后认知功能的影响[J].天津医科大学学报,2016,22(01):66.
　MENG Yun,ZHANG Hua,YU Yong-hao?.Effect of dexmedetomidine on cerebral oxygen saturation and cognitive function in elder patients during laparoscopic surgery [J].Journal of Tianjin Medical University,2016,22(05):66.
[3]李鹏昊,郝敬鹏,王晖,等.结直肠癌合并泌尿系统疾病的临床分析[J].天津医科大学学报,2020,26(06):553.
　LI Peng-hao,HAO Jing-peng,WANG Hui,et al.Clinical analysis of colorectal cancer with urinary system diseases[J].Journal of Tianjin Medical University,2020,26(05):553.
[4]竹丽萍,熊英,吴晓敏,等.天津市社区老年人膳食种类及膳食多样性与认知变化关联的前瞻性研究[J].天津医科大学学报,2022,28(02):191.
　ZHU Li-ping,XIONG Ying,WU Xiao-min,et al.A prospective study on the association between dietary types， dietary diversity and cognitive changes among community-based elderly in Tianjin[J].Journal of Tianjin Medical University,2022,28(05):191.
[5]于乐昌,杨立恒,张蔷.右美托咪定对老年脓毒症机械通气患者炎症和预后的影响[J].天津医科大学学报,2022,28(04):409.
　YU Le-chang,YANG Li-heng,ZHANG Qiang.Effect of dexmedetomidine on inflammation and prognosis in elderly patients with sepsis requiring mechanical ventilation[J].Journal of Tianjin Medical University,2022,28(05):409.
[6]寇钰,熊英,竹丽萍,等.天津市社区老年人身体活动能力与认知功能关联的横断面研究[J].天津医科大学学报,2023,29(01):59.
　KOU Yu,XIONG Ying,ZHU Li-ping,et al.A cross-sectional study on the association between physical activity function and cognitive function of the community-based elderly in Tianjin[J].Journal of Tianjin Medical University,2023,29(05):59.
[7]高犇,代星,李江.改良查尔森合并症指数对老年患者肝移植术后早期并发症的评估价值[J].天津医科大学学报,2023,29(02):178.
　GAO Ben,DAI Xing,LI Jiang.Evaluation of the modified Charlson comorbidity index for predicting early complications after liver transplantation in elderly patients[J].Journal of Tianjin Medical University,2023,29(05):178.

备注/Memo

备注/Memo:
基金项目 天津市卫生局重点攻关项目基金资助（12KG104）

作者简介 许丹丹（1989-），女，硕士在读，研究方向：临床检验诊断学；

通信作者：刘蕊，E-mail：lr3595@163.com。

更新日期/Last Update: 2016-09-20