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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

22卷

期数:

2016年03期

页码:

222-225

栏目:

临床医学

出版日期:

2016-05-20

文章信息/Info

Title:

Expression and significance of C1q/ TNF-related protein 6 in obese children

文章编号:

1006-8147（2016）03-0222-04

作者:

王 媛¹; 2;  刘戈力¹

（1.天津医科大学总医院儿科，天津，300052;2.天津市公安医院儿科，天津 300042）

Author(s):

WANG Yuan1; 2; LIU Ge-li¹

(1.Department of Pediatrics,General Hospital , Tianjin Medical University,Tianjin 300052,China；2. Department of Pediatrics，Public Security Hospital of Tianjin, Tianjin 300042, China)

关键词:

C1q/肿瘤坏死因子相关蛋白6 ; 肥胖儿童; 糖脂代谢

Keywords:

C1q/TNF-related protein 6 (CTRP6); obese children; glucose and lipid metabolism

分类号:

R589

DOI:

-

文献标志码:

A

摘要:

目的： 探讨肥胖儿童血清C1q/肿瘤坏死因子相关蛋白6(CTRP6)与体内抗炎因子和炎症因子的相互关系，及其对体格指标和糖脂代谢的影响。方法： 根据肥胖及代谢综合征的诊断标准将肥胖儿童分为代谢综合征组（62例）和单纯性肥胖组（77例），同时选取同期就诊的同年龄范围的体质量正常儿童62例为对照组。测定3组儿童体格参数、血常规、CTRP6、白介素-10（IL-10）、白介素-6（IL-6）和单核细胞趋化因子蛋白-1（MCP-1）浓度；代谢综合征组及单纯性肥胖组同时检测血脂、空腹血糖（FPG）和空腹胰岛素（FINS）。结果： 代谢综合征和单纯性肥胖组CTRP6及IL-10低于对照组，IL-6及MCP-1高于对照组，其中，代谢综合征组的CTRP6及IL-10又低于单纯性肥胖组，IL-6及MCP-1高于单纯性肥胖组，差别均有统计学意义（P＜0.05）。代谢综合征组的血清总胆固醇（TC），甘油三酯（TG），低密度脂蛋白胆固醇（LDL-C）、 FPG、FINS、胰岛素抵抗指数（HOMA-IR）高于单纯性肥胖组，高密度脂蛋白胆固醇（HDL-C）低于单纯性肥胖组，差别具有统计学意义（P＜0.05）。CTRP6与IL-10、HDL-C呈正相关；与IL-6、MCP-1、FPG、FINS、TG、TC、LDL-C呈负相关。多元逐步回归分析显示FPG、TG和MCP-1可能是CTRP6水平的独立关联因素。结论： CTRP6作为一种新型抗炎脂肪因子，对调节糖脂代谢有一定的作用，对改善肥胖所致的炎症状态及其相关并发症有重要意义。

Abstract:

Objective: To investigate the relationship between serum C1q/TNF-related protein 6 (CTRP6) and anti-inflammatory cytokines and（改为as well as） inflammatory factors in obese children, and to explore its impact on physical indicators and lipid metabolism. Methods: Metabolic syndrome group (62 cases) and the simple obesity group (77 cases) based on the diagnostic criteria of obesity and metabolic syndrome in obese children were involved , and 62 cases of children with body mass in normal range were set as control group at the same time. Children’s physical parameters, routine blood test, serum concentration of CTRP6, interleukin -10 (IL-10), interleukin -6 (IL-6) and monocyte chemoattractant factor protein -1 (MCP-1) in three groups were determined; while serum lipids, fasting plasma glucose (FPG) and fasting insulin (FINS) in metabolic syndrome group and the simple obesity group were obtained. Results: It is showed that simple obesity group had less metabolic syndrome, lower serum concentration of CTRP6 and IL-10 but higher serum concentration of IL-6 and MCP-1 than the control group. The similar result was obtained between the metabolic syndrme group and the simple obesity group, and the difference was statistically significant (P<0.05). Serum total cholesterol(TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), FPG, FINS, insulin resistance index (HOMA-IR)（加上were） higher in metabolic syndrome group than the simple obesity, but high density lipoprotein cholesterol (HDL-C) was lower compared with the simple obesity group, and the difference was statistically significant (P <0.05). CTRP6 was positively correlated with IL-10, HDL-C; and negatively correlated with IL-6, MCP-1, FPG, FINS, TG, TC, LDL-C. Stepwise regression analysis showed that FPG, TG, and MCP-1 were independent factors for CTRP6 levels. Conclusion: CTRP6, as a novel anti-inflammatory adipokines, could regulate glucose and lipid metabolism, which has significant influence on improving the state of obesity-induced inflammation and associated complications.

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相似文献/References:

备注/Memo

备注/Memo:

作者简介 王媛（1982-），女，主治医师，硕士在读，研究方向：儿科学；
通信作者： 刘戈力， E-mail：liugeli2001@126.com 。

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更新日期/Last Update: 2016-05-25