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[1]韩小磊,张 鹏,李 新,等.术前应用氨溴索对左心室舒张功能不全老年患者开胸术后疗效研究[J].天津医科大学学报,2016,22(02):160-163.
　HAN Xiao-lei,ZHANG Peng,LI Xin,et al.Study of curative effect on preoperative use of ambroxol in elderly patients with left ventricular diastolic dysfunction after thoracic surgeries[J].Journal of Tianjin Medical University,2016,22(02):160-163.
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术前应用氨溴索对左心室舒张功能不全老年患者开胸术后疗效研究(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
22卷
期数:
2016年02期
页码:
160-163
栏目:
临床医学
出版日期:
2016-03-20

文章信息/Info

Title:
Study of curative effect on preoperative use of ambroxol in elderly patients with left ventricular diastolic dysfunction after thoracic surgeries
文章编号:
1006-8147（2016）02-0160-04
作者:
韩小磊; 张 鹏; 李 新; 陈 渊
(天津医科大学总医院心胸外科,天津 300052)
Author(s):
HAN Xiao-lei;  ZHANG Peng;  LI Xin; CHEN Yuan
(Department of Cardiothoracic Surgery，General Hospital，Tianjin Medical University，Tianjin 300052，China)
关键词:
左心室舒张功能不全; 开胸手术; 氨溴索
Keywords:
left ventricular diastolic dysfunction ; thoracic surgery;  ambroxol
分类号:
R655
DOI:
-
文献标志码:
A
摘要:

目的：探讨术前应用氨溴索对左心室舒张功能不全老年患者开胸术后心肺功能的疗效。方法：收集入院需行开胸手术的老年患者88例，患者均合并左心室舒张功能不全，6分钟步行试验步行距离>300 m，随机分为试验组与对照组，试验组术前应用氨溴索治疗，对照组应用安慰剂。术前3 d及术后3 、8 d行静态肺功能及超声心动及组织多普勒检查及术后3 d检测血清B型脑钠肽（BNP）、C反应蛋白 (CRP)、降钙素原（PCT），监测患者生命体征及术后心肺并发症发生情况，将这些指标进行分析比较。结果：试验组术后肺功能及心功能均优于对照组，P<0.05。患者术后生命体征及动脉血气分析提示试验组基础状态比对照组更稳定，p<0.05。BNP、CRP、PCT检验指标低于对照组，P<0.05. 试验组患者术后肺感染、肺不张、心衰、心律失常等心肺并发症的发生率低于对照组，P<0.05。结论：患者术前应用氨溴索可以减少手术对患者的创伤，改善患者术后心肺功能，减少患者心肺并发症发生率，有助于患者更好的应对手术，减少不良预后。

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Abstract:
Objective: To investigate curative effect of preoperative use of ambroxol in elderly patients with left ventricular diastolic dysfunction after thoracic surgeries. Methods: Eighty eight cases of elderly patients in hospital were collected，who all had left ventricular diastolic dysfunction, but whose six minutes walking distance>300 m. The patients were divided into experimental group and control group, ambroxol were used pre-operation, while placebo were used in the control group. Static pulmonary function, Doppler ultrasound, C reactive protein (CRP), brain natriuretic peptide(BNP), procalcitonin(PCT) were detected 3 days before and after the operation ,8 days after operation. Vital signs and complications of heart and lung post operation were also monitored and analyzed. Results: The lung function and heart function in the experimental group were better than those in the control group, (P<0.05).The vital signs and arterial blood gas of the patients in the experimental group after the thoracic surgeries were more stable than those in the control group, P<0.05.Laboratorial index includes BNP,CRP ,PCT of the experimental group was lower than that in the control group, (P<0.05).The incidence of pulmonary infection ,pulmonary atelectasis, heart failure, arrhythmia in the experimental group after the thoracic surgeries were lower than that in the control group, （P<0.05）.Conclusion: Preoperative use of ambroxol can reduce the surgical trauma, improve heart and lung function in patients after the thoracic surgeries, as well as decrease the incidence of lung and heart complications. It also can help patients better adapt to the operation, leading to lower adverse effect.

参考文献/References:

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相似文献/References:

[1]郭 峰,张 鹏.老年患者开胸术后急性呼吸衰竭不同治疗方案疗效比较[J].天津医科大学学报,2014,20(01):48.
　GUO Feng,ZHANG Peng.Comparative study on different treatments of postoperative acute respiratory failure by thoracotomy in elderly patients[J].Journal of Tianjin Medical University,2014,20(02):48.

备注/Memo

备注/Memo:
作者简介 韩小磊(1989- ),男，硕士在读，研究方向：胸心外科及胸部肿瘤学临床和基础研究；通信作者：张鹏， E-mail：zhp_tjgh@yahoo.com.cn。
更新日期/Last Update: 2016-03-23