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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

22卷

期数:

2016年01期

页码:

37-40

栏目:

临床医学

出版日期:

2016-01-20

文章信息/Info

Title:

Clinical evaluation on procalcitonin in identifying bloodstream infection caused by different pathogens

文章编号:

1006-8147（2016）01-0037-04

作者:

?蔡 鲜; 胡志东; 余 倩; 李妍淳; 李 金; 徐海茹

?（天津医科大学总医院检验科，天津300052）

Author(s):

CAI Xian;  HU Zhi-dong;  YU Qian;  LI Yan-chun;  LI Jin;  XU Hai-ru

（Department of Clinical Laboratory, General Hospital, Tianjin Medical Univer-sity, Tianjin 300052, China）

关键词:

降钙素原; 血流感染; 定量检测; 污染

Keywords:

procalcitonin;  bloodstream infection;  quantitative detection; contamination

word-break: break-all; " />

分类号:

R631

DOI:

-

文献标志码:

A

摘要:

目的： 探讨降钙素原（PCT）定量检测在区分不同病原体引起的血流感染及鉴别诊断凝固酶阴性葡萄球菌（CNS）血流感染中的临床应用价值。 方法：选取531例同时送检血培养及PCT患者资料进行回顾性分析。采用ROC曲线确定降钙素原的Cut-off值，采用秩和检验比较PCT在血培养阴性与阳性组间、不同病原体组间结果有无差异。采用t检验比较CNS血流感染组与血培养污染组间结果有无差异。结果： PCT区分血培养阴性与阳性、革兰氏阴性菌与革兰氏阳性菌、CNS血流感染与血培养污染的最佳截断值分别为1.31 ng/mL、16.45ng/mL、1.34 ng/mL。PCT在血培养阴性与阳性组、革兰氏阴性菌与革兰氏阳性菌组、革兰氏阴性菌与真菌组以CNS血流感染组与血培养污染组之间差异有统计学意义（P<0.05）。结论： PCT定量检测对预判血流感染、区分革兰氏阴性菌与革兰氏阳性菌或真菌血流感染及鉴别诊断CNS引起的血流感染具有较好的应用价值。

Abstract:

Objective: To explore the clinical value of PCT levels in identifying bloodstream infection caused by different pathogens and for differentiating coagulase negative staphylococcus (CNS) bloodstream infection and contamination. Methods: Medical records of 531 patients who underwent blood culture test and PCT at the same time were retrospectively analyzed. ROC curve was used to determine the cut-off value of PCT. Nonparametric comparisons between positive and negative blood culture or multi-group comparisons were done by rank sum test. T test was applied to compare CNS bloodstream infection and blood culture contamination group. Results: The optimal cut-off values of PCT for predicting a positive blood culture, distinguishing Gram-positive（G⁺） bacteria and Gram-negative（G^-）bacteria , differentiating CNS bloodstream infection and contamination were 1.31 ng/mL, 16.45 ng/mL ,1.34 ng/mL respectively. PCT were significantly elevated in patients whose blood cultures were positive than the patients who had negative cultures（P<0.05）. In addition, PCT was significantly higher in patients with G- bacteria than inpatients with a G+ bacteria or fungi（P<0.05）.It also had significant differences between CNS bloodstream infection and contamination（P<0.05）. Conclusion: PCT is highly effective in distinguishing negative and positive bacteria or fungi bloodstream infection. In addition, PCT is also good for differentiating CNS bloodstream infection and contamination.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介：蔡鲜（1991-），女，硕士在读，研究方向：细菌耐药机制;

通信作者：胡志东，E-mail：huzhidong27@163.com。

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更新日期/Last Update: 2016-01-25