|本期目录/Table of Contents|

[1]邱 丽,苗 温,白 虹.O型孕妇产前IgG抗-A(B)抗体效价变化分析[J].天津医科大学学报,2016,22(01):31-33.
　QIU Li,MIAO Wen,BAI Hong.Analysis of IgG anti -A (B) antibody titers in type O pregnant women[J].Journal of Tianjin Medical University,2016,22(01):31-33.
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O型孕妇产前IgG抗-A(B)抗体效价变化分析(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
22卷
期数:
2016年01期
页码:
31-33
栏目:
临床医学
出版日期:
2016-01-20

文章信息/Info

Title:
Analysis of IgG anti -A (B) antibody titers in type O pregnant women
文章编号:
1006-8147（2016）01-0031-03
作者:
邱 丽1; 苗 温2; 白 虹1
(1.天津医科大学基础医学院免疫学系,天津300070;2.天津市滨海新区塘沽中心血站,天津300456)
Author(s):
QIU Li1; MIAO Wen2; BAI Hong1△
（1.Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China；2. Binhai Tanggu Blood Station, Tianjin 300456, China）
关键词:
IgG抗-A(B)抗体 ;  新生儿溶血病 ;  拐点
Keywords:
IgG anti-A (B) antibody; haemolytic disease of the newborn; turning point
分类号:
R722.18
DOI:
-
文献标志码:
A
摘要:
目的：探讨O型孕妇产前IgG抗-A(B)抗体效价的变化及其拐点的出现时间。方法：使用经典抗球蛋白试验检测2 777名O型孕妇血清中IgG抗-A(B)抗体效价，并按妊娠次数、孕周进行结果分析。结果：随着妊娠次数的增加，血清中IgG抗-A(B)抗体水平也不断增高，首次妊娠与2次及以上妊娠孕妇血清IgG抗-A(B)抗体效价相比均存在显著性差异（P＜0.01）；随着孕周的增加，血清中IgG抗-A(B)抗体水平在16～19周时缓慢增高，在妊娠20周时出现一个明显增高的拐点，而后继续增高并在孕24～28周时达到峰值，随后不再增长。结论：O型孕妇在妊娠20周时应进行IgG抗-A(B)抗体效价检测，具有多次妊娠史的O型孕妇，体内可能存在高效价的IgG抗-A(B)抗体，应及时进行抗体检测。
Abstract:

Objective ：To investigate the changes and turning point of IgG anti-A(B) antibody titers of type O pregnant women. Methods：IgG anti-A(B) antibody titers of 2 777 type O pregnant women were tested by the classic antiglobulin test and the results were analyzed according to the number of pregnancy and gestational weeks. Results：With the increase of the number of pregnancy, serum IgG anti -A (B) antibody levels were also increased, and significant difference was found in IgG anti -A (B) antibody titers between the first pregnancy and the two or multiple pregnant women（P＜0.01）. With the increase of gestational weeks, serum IgG anti -A (B) antibody level was first increased slowly in 16-19 weeks of pregnancy, with a turning point of marked increase at 20 weeks of pregnancy，after which continued to increase to peak at 24-28 weeks of pregnancy, without any further growth. Conclusion： The type O pregnant women should undergo IgG anti-A (B) antibody titers detection at 20 weeks of pregnancy. The group O pregnant women with multiple pregnancy history should carry out IgG anti -A (B) antibody test in time, because high titer antibodies may exist in their sera.

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备注/Memo

备注/Memo:
作者简介 邱丽（1982-），女，硕士在读，研究方向：免疫学；通信作者：白虹，E-mail：hongbai25@163.com。
更新日期/Last Update: 2016-01-25