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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

21卷

期数:

2015年01期

页码:

55-58

栏目:

临床医学

出版日期:

2015-01-20

文章信息/Info

Title:

Effect of small-dose erythromycin on serum TGF-β and IL-13 in patients with  idiopathic pulmonary fibrosis

文章编号:

1006-8147（2015）0-0055-04

作者:

朱晓颖¹; 王 燕²; 闫 欢³; 郭美南⁴; 胡志东³

(1.天津医科大学研究生院,天津300070;2.天津医科大学总医院肿瘤科,天津300052;3.天津医科大学总医院免疫室,天津300052;4.天津医科大学总医院呼吸科,天津300052)

Author(s):

ZHU Xiao-ying¹; WANG Yan²; YAN Huan³; GUO Mei-nan⁴; HU Zhi-dong³

(1.Graduate School，Tianjin Medical University，Tianjin 300070，China；2.Department of Oncology，General Hospital，Tianjin Medical University，Tianjin 300052，China；3.Laboratory of Immunology，General Hospital，Tianjin Medical University，Tianjin 300052，China；4.Department of Respiratory，General Hospital，Tianjin Medical University，Tianjin 300052 ，China)

关键词:

特发性肺间质纤维化; 转化生长因β; 白介素13 ; 红霉素

Keywords:

 ; idiopathic pulmonary fibrosis; transforming growth factor-β;  IL-13; erythromycin

分类号:

R563

DOI:

-

文献标志码:

A

摘要:

目的：探讨小剂量红霉素对特发性肺间质纤维化血清转化生长因β（TGF-β）、白介素13（IL-13）的影响。方法：将39例特发性肺纤维化患者随机分为常规治疗组（A组）和小剂量红霉素治疗组（B组），采用双抗体夹心ABC-ELISA法对肺间质纤维化两组及健康对照组（C组）血清TGF-β、IL-13进行测定。结果：A、B两组血清TGF-β及IL-13水平均明显高于C组（P <0.05， P<0.05）。治疗后B组动脉血氧饱和度(SaO2 )明显高于A组，差异有显著性（P<0.05）；B组血清TGF-β、IL-13水平均低于A组，但差异无显著性（P>0.05）。血清TGF-β、IL-13水平与血氧分压、血氧饱和度、肺泡-动脉氧分压差（AaDO2 ）无直线相关关系。结论：细胞因子的紊乱与特发性肺间质纤维化有密切关系，红霉素可影响特发性肺间质纤维化的炎症反应，改善缺氧。

Abstract:

Objective: To investigate the effect of small-dose erythromycin on serum TGF-β and IL-13 in patients with idiopathic pulmonary fibrosis. Methods: Thirty-nine patients with idiopathic pulmonary fibrosis were randomly divided into two groups, conventional glucocorticoid treatment was used in 20 cases (Group A) and small-dose erythromycin was administrated in another 19 cases (Group B). Serum transforming growth factor-β (TGF-β) and interleukin-13 (IL-13) were detected in group A and B and healthy controls (Group C) by double antibody sandwich ABC-ELISA. Results: Serum TGF-β and IL-13 levels of both group A and group B were significantly higher than those of control (P<0.001, P<0.05, respectively). The average level of SaO₂ in Group B was significantly higher than that in Group A after treatment of small-dose erythromycin. No linear correlation was found between serum level of TGF-β and IL-13 and PO₂, SaO₂, and AaDO₂. Conclusion: Disorder of cytokines is associated with idiopathic pulmonary fibrosis, and small-dose erythromycin treatment could mitigate inflammation in idiopathic pulmonary fibrosis.

参考文献/References:

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相似文献/References:

[1]朱晓颖,王 燕,闫 欢,等.小剂量红霉素对肺间质纤维化血清TGF-β、IL-13的影响[J].天津医科大学学报,2015,21(03):55.
　ZHU Xiao-ying,WANG Yan,YAN Huan,et al.Effect of small-dose erythromycin on serum TGF-β and IL-13 in patients with idiopathic pulmonary fibrosis[J].Journal of Tianjin Medical University,2015,21(01):55.

备注/Memo

备注/Memo:

 基金项目 天津医科大学科研基金资助项目(2003KY63)

作者简介 朱晓颖，(1981- )，女，硕士在读，研究方向：呼吸系统疾病；通信作者：王燕，E-mail：wangyan5701@sohu.com.。

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更新日期/Last Update: 2015-06-11