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[1]明 慧,张桂芝,李 玮,等.分化型甲状腺癌患者肝功能损害与甲状腺功能减退的关系[J].天津医科大学学报,2015,21(06):514-517.
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分化型甲状腺癌患者肝功能损害与甲状腺功能减退的关系(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21卷
期数:
2015年06期
页码:
514-517
栏目:
临床医学
出版日期:
2015-11-20

文章信息/Info

Title:
-
文章编号:
1006-8147（2015）06-0514-04
作者:
明 慧; 张桂芝; 李 玮; 李承霞; 谭 建
（天津医科大学总医院核医学科，天津 300052）
Author(s):
-
关键词:
DTC; 131I; 甲状腺功能减退; 肝功能损害
Keywords:
-
分类号:
R817
DOI:
-
文献标志码:
A
摘要:
目的：研究分化型甲状腺癌（DTC）患者131I治疗前肝功能损害与甲状腺功能减退的关系。方法：收集拟行131I治疗前的200例DTC患者的临床资料，并根据患者接受131I治疗前促甲状腺激素（TSH）值的不同，将其分为1组（TSH<30 mU/L）、2组（30 mU/L <TSH<100 mU/L）、3组（100 mU/L <TSH<150 mU/L）、4组（TSH>150 mU/L）。根据各组临床资料，使用SPSS17.0软件进行单因素方差分析、独立样本t检验、Pearson及Spearman相关分析其差异。结果：200例患者中肝功能正常组145例，肝功能异常组55例，其中肝功能异常组中丙氨酸转氨酶（ALT）异常者36例、天冬氨酸转氨酶（AST）异常者18例、γ谷氨酰转肽酶（γ-GGT）异常者18例、总胆红素（TBIL）及直接胆红素（DBIL）异常者8例。当TSH处于不同阶段时，相应的血清白蛋白、ALT、AST及碱性磷酸酶均值未见明显差异（p>0.05）。但当30 mU/L <TSH<100 mU/L，其相对应的γ-GGT、TBIL及DBIL均高于TSH>150 mU/L组(p<0.05)。性别、年龄及TSH值对于肝功能的影响有统计学意义（p <0.05）。是否伴有桥本甲状腺炎及是否合并局部或远处转移对肝功能无明显影响（p>0.05）。结论： DTC患者131I治疗前甲状腺功能减退对肝脏转氨酶无明显影响，主要引起肝脏γ谷氨酰转肽酶、总胆红素及直接胆红素的异常升高。
Abstract:
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参考文献/References:

[1]甲状腺结节和分化型甲状腺癌诊治指南[J]．中国肿瘤临床，2012，33（17）：1249

[2]代文莉，崔邦平，胡涛，等．甲状腺癌~(131)Ⅰ治疗对肝肾功能及白细胞影响[J]．现代肿瘤医学，2012，20（1）：59

[3]吴书其，李瑾，叶智轶，等．分化型甲状腺癌~(131)Ⅰ治疗对患者肝肾功能的影响[J]．上海交通大学学报:医学版，2010，30（3）：271

[4]周燕，王绩凯，黄凯，等．脂肪肝患者肝功能与血脂水平关系[J]．中国公共卫生，2011，27（1）：101

[5]Yao X, Hou S, Zhang D, et al. Regulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver[J]. Cell Biosci, 2014, 4: 38

[6]Sinha R A, Singh B K, Yen P M. Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism[J]. Trends Endocrinol Metab., 2014, 25(10):538

[7]Santana-Farré R, Mirecki-Garrido M, Bocos C, et al. Influence of neonatal hypothyroidism on hepatic gene expression and lipid metabolism in adulthood[J]. PLoS One, 2012, 7(5): e37386.

[8]Burra P. Liver abnormalities and endocrine diseases[J]. Best Pract Res Clin Gastroenterol, 2013, 27(4): 553

[9]Tajiri J, Shimada T, Naomi S, et al. Hepatic dysfunction in primary hypothyroidism[J]. Endocrinol Jpn, 1984, 31(1): 83

[10]李春枝，卫海燕，古建平，等．先天性甲状腺功能减退症对儿童肝功能的影响[J]．中国现代医生，2013，51（23）：23

[11]Targher G, Montagnana M, Salvagno G, et al. Association between serum TSH, free T4 and serum liver enzyme activities in a large cohort of unselected outpatients[J]. Clin Endocrinol (Oxf), 2008, 68(3): 481

[12]Gattani A G, K K, Moolchandani A, et al. The influence of experimental hypothyroidism on hepatic and renal function in rams in an arid tropical environment[J]. Veterinarski Arhiv, 2013, 83(2): 161

[13]Cano-Europa E, Blas-Valdivia V, Lopez-Galindo G E, et al. Methimazole-induced hypothyroidism causes alteration of the REDOX environment, oxidative stress, and hepatic damage; events not caused by hypothyroidism itself[J]. Ann Hepatol, 2010, 9(1): 80

[14]Laukkarinen J, Sand J, Saaristo R, et al. Is bile flow reduced in patients with hypothyroidism?[J]. Surgery, 2003, 133(3): 288

[15]Malik R, Hodgson H. The relationship between the thyroid gland and the liver[J]. QJM, 2002, 95(9): 559

[16]Van Steenbergen W, Fevery J, De Vos R, et al. Thyroid hormones and the hepatic handling of bilirubin[J]. I.Effects of hypothyroidism and hyperthyroidism on the hepatic transport of bilirubin mono-and diconjugates in the Wistar rat[J]. Hepatology, 1989, 9(2): 314

[17]Laukkarinen J, Kiudelis G, Lempinen M, et al. Increased prevalence of subclinical hypothyroidism in common bile duct stone patients[J]. J Clin Endocrinol Metab, 2007, 92(11): 4260

[18]Inkinen J, Sand J, Nordback I. Association between common bile duct stones and treated hypothyroidism[J]. Hepatogastroenterology, 2001, 47(34): 919

[19]Ajala M O, Ogunro P S, Fasanmade O A. Relationship between liver function tests and thyroid hormones in thyroid disorders[J]. Niger Postgrad Med J, 2013, 20(3): 188

[20]Oren R, Brill S, Dotan I, et al. Liver function in cirrhotic patients in the euthyroid versus the hypothyroid state[J]. J Clin Gastroenterol, 1998, 27(4): 339

[21]Bruck R, Frenkel D, Shirin H, et al. Hypothyroidism protects rat liver from acetaminophen hepatotoxicity[J]. Dig Dis Sci, 1999, 44(6): 1228

[22]Bruck R, Oren R, Shirin H, et al. Hypothyroidism minimizes liver damage and improves survival in rats with thioacetamide induced fulminant hepatic failure[J]. Hepatology, 1998, 27(4): 1013

[23]Oren R, Sikuler E, Wong F, et al. The effects of hypothyroidism on liver status of cirrhotic patients[J]. J Clin Gastroenterol, 2000, 31(2): 162

[24]Oren R, Dotan I, Brill S, et al. Altered thyroid status modulates portal pressure in normal rats[J]. Liver, 1999, 19(5): 423

[25]Grant N. The role of triiodothyronine-induced substrate cycles in the hepatic response to overnutrition: thyroid hormone as an antioxidant[J]. Med Hypotheses, 2007, 68(3): 641

[26] Ohkubo K, Ihara K, Ohga S, et al. Hypothyroidism and levothyroxine-responsive liver dysfunction in a patient with ring chromosome 18 syndrome [J]. Thyroid, 2012, 22(10): 1080

[27]Tozzoli R, Sorrentino M C, Bizzaro N. Detecting multiple autoantibodies to diagnose autoimmune co-morbidity (multiple autoimmune syndromes and overlap syndromes): a challenge for the autoimmunologist[J]. Immunol Res, 2013, 56(2/3): 425

[28]Teufel A, Weinmann A, Kahaly G J, et al. Concurrent autoimmune diseases in patients with autoimmune hepatitis[J]. J Clin Gastroenterol, 2010, 44(3): 208

[29]Efe C, Wahlin S, Ozaslan E, et al. Autoimmune hepatitis/primary biliary cirrhosis overlap syndrome and associated extrahepatic autoimmune diseases[J]. Eur J Gastroenterol Hepatol, 2012, 24(5): 531

[30]Choudhuri G, Somani S K, Baba C S, et al. Autoimmune hepatitis in India:profile of an uncommon disease[J]. BMC Gastroenterol, 2005, 5:27

[31]Biró E, Szekanecz Z, Czirják L, et al. Association of systemic and thyroid autoimmune diseases[J]. Clin Rheumatol, 2006, 25(2): 240



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备注/Memo

备注/Memo:
作者简介 明慧（1989-），女，硕士在读，研究方向：影像医学与核医学；通信作者：谭建，E-mail：tanpost@163.com。
更新日期/Last Update: 2015-11-27