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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

21卷

期数:

2015年03期

页码:

248-251

栏目:

临床医学

出版日期:

2015-05-20

文章信息/Info

Title:

Association of metabolism syndrome and its components with serum  γ--glutamyl transpeptidase in patients with type 2 diabetes

文章编号:

1006-8147（2015）03-0248-04

作者:

张 甜; 李明珍; 孙丽荣; 耿思思; 郭亚楠

(天津医科大学代谢病医院糖尿病痛风科,天津 300070)

Author(s):

ZHANG Tian;  LI Ming-zhen;  SUN Li-rong;  GENG Si-si;  GUO Ya-nan

(Department of Gout, Metabolic Diseases Hospital, Tianjin Medical University, Tianjin 300070, China)

关键词:

2型糖尿病; 谷氨酰转肽酶; 代谢综合征

Keywords:

diabetes mellitus; type 2;  γ-glutamyl transpeptidase; metabolic syndrome

分类号:

R587.1

DOI:

-

文献标志码:

A

摘要:

目的: 探讨2型糖尿病（T2DM）患者代谢综合征（MS）组分与血清谷氨酰转肽酶（γ-GGT）的相关性。方法:445例T2DM患者按MS组分数目分为A、B、C、D组，分别包含1、2、3、4个MS组分，按血清γ-GGT水平分为正常组与异常组，比较不同组间γ-GGT、血糖、血压、血脂、胰岛素及胰岛素抵抗指数(HOMA-IR)等指标。结果:(1) 随MS组分的增加，BMI、TG、SUA、γ-GGT水平逐渐升高，差异有统计学意义（P＜0.05）；C、D组SBP、DBP、TC、LDL-C、HDL-C、HOMA-IR明显高于A、B组，D组HDL-C高于C组，B组DBP、HOMA-IR高于A组，差异有统计学意义（P＜0.05）。（2）γ-GGT异常组年龄轻、病程短，且BMI、DBP、TG、FIns、HOMA-IR、SUA、ALT、AST高于正常组（P＜0.05）。（3）Pearson相关分析显示，γ-GGT与BMI、DBP、SUA、TG、FIns、HOMA-IR呈正相关（r=0.296、0.134、0.411、0.106、0.089、0.082，P＜0.05），与年龄、病程呈负相关（r=-0.088、-0.188，P＜0.05）。多元逐步线性回归分析显示，γ-GGT与BMI、SUA、TG、HOMA-IR呈正相关（B=0.016、0.002、0.081、0.078，P＜0.05），与病程呈负相关（B=-0.011，P＜0.05）。（4）Logistic回归分析示，BMI、TG、FIns、SUA是血清γ-GGT升高的独立危险因素。结论:T2DM患者MS组分与血清γ-GGT水平密切相关，BMI、TG、FIns、SUA是血清γ-GGT升高的独立危险因素。

Abstract:

Objective: To investigate the association of metabolism syndrome（MS）and its components with serum γ-glutamyl transpeptidase（γ-GGT） in patients with type 2 diabetes. Methods： Four hundred and forty five type 2 diabetic patients according to the MS group number were divided into A, B, C and D group, respectively with 1, 2, 3, 4 MS components. And then patients were divided into normal and abnormal groups according to the levels of serumγ-GGT. γ-GGT, blood glucose, blood pressure, blood lipid, insulin and insulin resistance index (HOMA-IR) and other indicators of different groups were compared. Results：(1) As the increase of MS component, the level of BMI，TG，SUA，γ-GGT increased gradually(P＜0.05)；Compared with group A，B, the levels of SBP，DBP，TC，LDL-C，HDL-C，HOMA-IR increased significantly in group C, D and the level of HDL-C in group D was higher than group C. The level of DBP, HOMA-IR in group B were higher than group A(P＜0.05). (2) Abnormal γ-GGT group presented with young age and short duration, and compared with normal group, the levels of BMI, DBP, TG, FIns, HOMA-IR, (3 SUA，ALT，AST in the group increased significantly (P＜0.05).) Pearson correlation analysis revealed γ-GGT had a positive was positively correlated with BMI, DBP, SUA, TG, FIns, HOMA-IR（r=0.296，0.134，0.411，0.106，0.089，0.082，P＜0.05），and a negative correlation with age and duration（r=-0.088，-0.188，P＜0.05）. Multiple linear regression showed γ-GGT was positively correlated with BMI，SUA，TG, HOMA-IR（B=0.016，0.002，0.081，0.078，P＜0.05），and a negative correlation with duration（B=-0.011，P＜0.05）.(4)Logistic regression showed BMI, TG, FIns, SUA were independent risk factors for elevated surem γ-GGT. Conclusion: In patients with type 2 diabetes, MS and its components are closely corelated with surem γ-GGT and BMI，TG，Fins and SUA are independent risk factors for elevated surem γ-GGT.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介 张甜（1988-），女，硕士在读，研究方向：2型糖尿病与痛风，高尿酸血症基础与临床研究；

通信作者：孙丽荣，E-mail: sunlirong10@sina.com。

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更新日期/Last Update: 2015-05-27