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[1]张成龙,郇 娟,师 伟,等.降钙素原和C反应蛋白诊断尿脓毒症的价值[J].天津医科大学学报,2015,21(02):147-149.
　ZHANG Cheng-long,HUAN Juan,SHI Wei,et al.Value of procalcitonin and C reactive protein in diagnosis of urosepsis[J].Journal of Tianjin Medical University,2015,21(02):147-149.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21卷
期数:
2015年02期
页码:
147-149
栏目:
临床医学
出版日期:
2015-03-20

文章信息/Info

Title:
Value of procalcitonin and C reactive protein in diagnosis of urosepsis
文章编号:
1006-8147（2015）02-0147-03
作者:
张成龙; 郇 娟; 师 伟; 韩双羽; 王 哲; 郭文学; 贾宇驰; 王玉宝
(天津医科大学第二医院感染性疾病研究所,天津 300211)
Author(s):
ZHANG Cheng-long;  HUAN Juan;  SHI Wei;  HAN Shuang-yu;  WANG Zhe;  GUO Wen-xue;  JIA Yu-chi;  WANG Yu-bao
(Institute of Infectious Diseases, The Second Hospital ,Tianjin Medical University, Tianjin 300211, China)
关键词:
尿脓毒症; 泌尿系感染; 降钙素原; C反应蛋白; ROC曲线
Keywords:
urosepsis;  urinary tract infection;  procalcitonin;  C-reactive protein;  ROC curve
分类号:
R631
DOI:
-
文献标志码:
A
摘要:
 目的： 探讨降钙素原（PCT）和C反应蛋白（CRP）对尿脓毒症的诊断价值。 方法： 将102例符合纳入标准的泌尿系感染患者分为尿脓毒症组和非尿脓毒症组，比较尿脓毒症和非尿脓毒症患者血清PCT和CRP之间的差异，并绘制PCT和CRP诊断尿脓毒症的受试者工作曲线（ROC）。　结果：102例泌尿系感染患者中，尿脓毒症患者43例，非尿脓毒症患者59例；尿脓毒症组PCT、CRP显著高于非尿脓毒症组（P 均<0.001）；PCT、CRP在尿脓毒症的ROC曲线下面积分别是0.759、0.710（95%置信区间0.608～0.811、0.666～0.851），在各自最佳工作位点，PCT和CRP诊断尿脓毒症的敏感性分别是0.907和0.419，特异性分别是0.610和0.932，阳性预测值分别是0.629和0.818，阴性预测值分别是0.900和0.688。 结论： PCT和CRP是诊断尿脓毒症的良好指标。
Abstract:

Objective: To investigate the roles of procalcitonin (PCT) and C-reactive protein (CRP) serum concentrations in the diagnose of urosepsis. Methods： 102（改为One hundred and two） patients with uriary tract infection (UTI) were divided into urosepsis group and non-urosepsis group. The PCT and CRP serum concentrations were compared between urosepsis group and non-urosepsis group, and the receiver operating characteristic (ROC) curves were constructed. Results: Forty-three patients were with urosepsis and 59 patients without urosepsis. Compared with the non-urosepsis group, the serum concentrations of PCT and CRP increased significantly in the urosepsis group (P<0.001). The area under ROC curve of PCT and CRP diagnosing urosepsis were 0.759 (95% CI): 0.608～0.811) and 0.710 (95% CI: 0.666～0.851)， respectively. At the optimal operating points, the sensitivity, specificity, positive predictive value and negative predictive value of PCT and CRP diagnosing urosepsis were 0.907, 0.419, 0.610, 0.932, 0.629, 0.818, 0.900 and 0.688 respectively. Conclusion： PCT and CRP are effective biomarkers for urosepsis.

 

参考文献/References:

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[11]黄新文，王晋鹏，李海林．血清C-反应蛋白与降钙素原水平对细菌性脓毒症的诊断价值[J]．中华医学杂志，2014，94（27）：2106

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备注/Memo

备注/Memo:

作者简介 张成龙（1989-），男，硕士在读，研究方向：细菌的致病及耐药机制；

通信作者：王玉宝，E-mail:wyb2046@163.com。

更新日期/Last Update: 2015-03-24