|本期目录/Table of Contents|

[1]吴 云,王 妍,余亚杰,等.血管中血栓流动及其影响的数值模拟[J].天津医科大学学报,2015,21(02):109-112.
　WU Yun,WANG Yan,YU Ya-jie,et al.Numerical simulation of the thrombus flow and its influences in blood vessels[J].Journal of Tianjin Medical University,2015,21(02):109-112.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
21卷
期数:
2015年02期
页码:
109-112
栏目:
基础医学
出版日期:
2015-03-20

文章信息/Info

Title:
Numerical simulation of the thrombus flow and its influences in blood vessels
文章编号:
1006-8147（2015）02-0109-04
作者:
吴 云1; 王 妍2; 余亚杰2;  许松林2
（1.天津市南开区王顶堤医院内科，天津 300190；2.天津大学化工学院制药工程系，系统生物工程教育部重点实验室，天津 300072）
Author(s):
WU Yun1; WANG Yan2; YU Ya-jie2;  XU Song-lin2
（1.Department of Medicine, Wangdingdi Hospital of Tianjin Nankai District, Tianjin 300190，China；2.Department of Pharmaceutical Engineering，School of Chemical Engineering and Technology，Tianjin University，Tianjin 300072，China)
关键词:

血栓; 血液流动; 壁面压强; 壁面剪切力

Keywords:
thrombus;  blood flow;  wall pressure;  wall shear stress
分类号:
R318
DOI:
-
文献标志码:
A
摘要:

目的：研究血液流动模式的改变对血栓形成的影响，分析血栓的存在对血管壁的压力和壁面剪切力造成影响的程度。方法：采用计算流体力学软件建立简化的2D血管模型，对血管中血栓和血液的两相流动进行数值模拟，研究血栓随血液流动的规律以及血栓大小、阻塞率及其不同存在形式对血管壁的影响，并对易产生血栓的部位进行分析预测。结果：血栓的大小和存在形式在流动上存在一定的差异，且与血液流动速度有关。结论：血栓的存在会导致血管壁的压力和壁面剪切力上升，从而对血管壁内膜造成损伤；血栓易形成于阻塞部位附近的低速区，阻塞率越大，血栓形成风险越大。

Abstract:
Objective: To study the effect of the blood flow patterns change on thrombus formation; and to study the impact of presence of thrombus on the vascular wall pressure and the wall shear stress. Methods: Computational fluid dynamics (CFD) software was used to establish simplified 2D vessel models, and the two-phase flow of blood and thrombus was simulated to study the rules of the thrombus flow as well as the influence of the size, and the influencethe blocking rate and different forms of thrombus on the vascular wall. Furthermore, the regions prone to thrombus formation were analyzed and predicted. Results: Research showed that the flow pattern of different presence forms and sizes of thrombus varied, and it was related to blood flow rate. Conclusion: Presence of thrombus can lead to pressure change and increased wall shear stress, causing damage to the vascular intimal. Thrombus in the low-speed regions near the site of the blockage are likely to form and the risk of thrombus formation is higher with the increasing of occlusion rate.

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备注/Memo

备注/Memo:
基金项目 国家自然科学基金项目21176170).
作者简介 吴云(1970-),女,主治医师,研究方向:内科理论与临床；通信作者：许松林，E-mail: slxu@tju.edu.cn.
更新日期/Last Update: 2015-03-24