|本期目录/Table of Contents|

[1]黄小娟,王俊艳,齐文慧,等.Axl及其配体Gas6在I型和 II型上皮性卵巢癌中的表达和意义[J].天津医科大学学报,2014,20(05):342-345.
　HUANG Xiao-juan,WANG Jun-yan,QI Wen-hui,et al.Expression of Axl and its ligand in type I and II epithelial ovarian carcinoma and its clinical significance[J].Journal of Tianjin Medical University,2014,20(05):342-345.
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Axl及其配体Gas6在I型和 II型上皮性卵巢癌中的表达和意义(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
20卷
期数:
2014年05期
页码:
342-345
栏目:
基础医学
出版日期:
2014-09-20

文章信息/Info

Title:
Expression of Axl and its ligand in type I and II epithelial ovarian carcinoma and its clinical significance
文章编号:
1006-8147(2014)05-0342-04
作者:

黄小娟 ; 王俊艳 ; 齐文慧 ; 王 立 ; 王世忠

(天津医科大学组织学与胚胎学教研室, 天津 300070)
Author(s):
HUANG Xiao-juan; WANG Jun-yan; QI Wen-hui; WANG Li; WANG Shi-zhong
(Department of Histology and Embryology, Tianjin Medical University, Tianjin 300070, China)
关键词:
上皮性卵巢癌; Axl; 生长停滞特异性蛋白6
Keywords:
epithelial ovarian carcinoma;  Axl;  growth arrest-specific protein 6
分类号:
R730.23
DOI:
-
文献标志码:
A
摘要:
目的：探讨Axl及其配体Gas6在I型和II型上皮性卵巢癌中的表达及临床意义。方法：免疫组化En Vision法检测121例恶性、交界性及良性卵巢上皮性肿瘤标本中Axl和Gas6的表达。结果：II型卵巢癌中Axl的阳性表达率显著高于I型卵巢癌（73.7% vs 43.8%,P<0.01）；前者Gas6的表达率也显著高于后者（89.5% vs 68.8%,P<0. 05）。恶性卵巢肿瘤中Axl及Gas6的阳性表达率高于交界性及良性肿瘤（P<0.05）。上皮性卵巢癌组织中Axl和Gas6的高表达与FIGO分期、远处转移及淋巴结转移密切相关（P<0. 05）。上皮性卵巢癌中Axl与Gas6的表达存在正相关性（x2=4.033,r=0.217;P<0.05）。结论：Axl及其配体Gas6是II型卵巢癌的分子标志物，二者的高表达与卵巢肿瘤恶性程度及肿瘤转移密切相关，两者结合可用作卵巢肿瘤转移及疾病进展的预测指标。
Abstract:
Objective: To examine the expression and the clinical significance of receptor tyrosine kinase Axl and its ligand Gas6 in type I and II epithelial ovarian carcinoma. Methods: Immunohistochemical method was used to detect Axl and Gas6 in 121 malignant, borderline and benign epithelial ovarian tumor specimens. Results: Positive expression of Axl and Gas6 in type II ovarian cancer was  significantly higher than that in type I. Expression of Axl and Gas6 in ovarian cancer was higher than control groups. Expression of Axl and Gas6 in ovarian cancer was closely correlated with FIGO stage, remote metastasis and lymph node metastasis. Furthermore, a positive correlation was found between Axl and Gas6 expressions in ovarian cancer. Conclusion: Axl and its ligand Gas6 are markers of type II ovarian cancer. Their high expressions are closely correlated with tumor malignancy degree and metastasis and they can be used to predict the metastasis and progression of epithelial ovarian tumor.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介 黄小娟（1987—），女，硕士在读，研究方向：肿瘤的血管生成机制和胚胎发育；通信作者：王俊艳，E-mail:junyan73@hotmail.com。
更新日期/Last Update: 2014-09-25