|本期目录/Table of Contents|

[1]孟令凯,何向辉,章志翔.微创介入治疗复发性肝癌临床疗效分析[J].天津医科大学学报,2014,20(02):144-146.
　MENG Ling-kai,HE Xiang-hui,ZHANG Zhi-xiang.Clinical curative effect of minimally invasive interventional treatment on recurrent liver cancer[J].Journal of Tianjin Medical University,2014,20(02):144-146.
点击复制

微创介入治疗复发性肝癌临床疗效分析(PDF)
分享到：

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
20卷
期数:
2014年02期
页码:
144-146
栏目:
临床医学
出版日期:
2014-03-20

文章信息/Info

Title:
Clinical curative effect of minimally invasive interventional treatment on recurrent liver cancer
文章编号:
1006-8147(2014)02-0144-03
作者:
孟令凯; 何向辉; 章志翔
(天津医科大学总医院普通外科,天津 300052)
Author(s):
MENG Ling-kai;  HE Xiang-hui;  ZHANG Zhi-xiang
(Department of General Surgery, General Hospital, Tianjin Medical University , Tianjin 300052, China)
关键词:
经皮肝射频消融术; 肝动脉化疗栓塞术; 介入治疗; 肝癌复发; 生存率
Keywords:
percutaneous radiofrequency ablation;  transcatheter arterial chemoembolization;  interventional therapy;  recurrence of hepatocellular carcinoma;  survival rate
分类号:
R735.7
DOI:
-
文献标志码:
A
摘要:
目的：评价经皮肝穿射频消融术(PRFA)联合肝动脉化疗碘油栓塞术(TACE)介入治疗复发性肝癌的临床效果，为临床制定以及选择治疗方法提供依据。方法： 收集复发性肝癌患者临床资料70例，均行超声引导下PRFA 联合TACE介入治疗。分析其近期临床治疗疗效并随访生存情况。结果：近期有效率( CR+ PR) 为85.71%, 甲胎蛋白（AFP）转阴率为75.0%, AFP下降超过50%者为95.83%，术后均有不同程度的消化道反应、肝脏生化指标改变等，6例发生较重并发症（肝功能衰竭1例、腹水2例、胆囊炎3例），积极纠正无治疗期死亡。6个月、12个月、24 个月生存率分别为76.3%、52.6%、34.2%。结论：PRFA联合TACE治疗无手术适应征的复发性肝癌近期疗效确切，可获得满意的远期生存时间，是非手术综合治疗中安全有效的方法之一，值得临床推广。
Abstract:
Objective: To evaluate the clinical efficacy of percutaneous radiofrequency ablation (PRFA) combined with transcatheter arterial chemoembolization (TACE) in the treatment of postoperative recurrence of primary hepatic carcinoma and provide a basis for the selection of clinical treatment. Methods: Clinical data of 70 patients with recurrent hepatic carcinoma after underwent hepatectomy with complete resection of tumor were collected. The interventional therapy that combined ultrasound-guided PRFA with TACE was applied to the recurring patients. Recent clinical efficacy and survival rates were analyzed. Results: Recent clinical efficacy rate (complete relief & partial relief) was 85.71% while the negative conversion rate and 50% descending rate of AFP were 75.0% and 95.83%, respectively. All cases had different degrees of the digestive tract reaction, hepatic postoperative biochemical index change, etc. Six cases had more severe complications (liver failure in 1 case, ascites in 2 cases, cholecystitis in 3 cases）, with no mortality after active treatment during therapy period. The survival rates in 6, 12, 24 months were 76.3%, 52.6%, 34.2%, respectively. Conclusion: The recent clinical efficacy of PRFA combined with TACE in the treatment of recurrent liver cancer is reliable, with convinced long-term survival. The interventional therapy that combines PRFA with TACE, serving as one of the safe and effective non-surgical treatment means, would be recommended.

参考文献/References:

[1]Shah S A, Greig P D, Gallinger S, et al. Factors associated with early recurrence after resection for hepatocellular carcinoma and outcomes[J]. J Am Coll Surg, 2006, 202(2): 275
[2] Cha C, Fong Y, Jarnagin W R, et al. Predictors and patterns of recurrence after resection of hepatocellular carcinoma[J]. J Am Coll Surg, 2003, 197(5): 753
[3] Hirokawa F, Hayashi M, Miyamoto Y, et al. Appropriate treatment strategy for intrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma[J]. J Gastrointest Surg, 2011, 15(7): 1182
[4] Xie X, Dendukuri N, McGregor M. Percutaneous radiofrequency ablation for the treatment of early stage hepatocellular carcinoma: A health technology assessment[J]. Int J Technol Assess Health Care, 2010, 26(4): 390
[5] 张智坚, 吴孟超, 陈汉, 等. 经皮肝穿刺射频热凝与肝动脉化疗栓塞联合治疗肝细胞癌[J]. 中华外科杂志, 2002, 40(11): 826
[6] 吴孟超, 陈汉, 沈锋. 原发性肝癌的外科治疗——附 5524 例报告[J]. 中华外科杂志, 2001, 39(1): 25
[7] 陆才德, 彭淑牖, 彭承宏, 等. 肝癌术后复发疗效和预后因素分析[J]. 中国实用外科杂志, 2000, 20(3): 144
[8] Poveda A, Kaye S B, McCormack R, et al. Circulating tumor cells predict progression free survival and overall survival in patients with relapsed/recurrent advanced ovarian cancer[J]. Gynecol Oncol ，2011, 122(3): 567
[9] Bhosale P, Peungjesada S, Wei W, et al. Clinical utility of positron emission tomography/computed tomography in the evaluation of suspected recurrent ovarian cancer in the setting of normal CA-125 levels[J]. Int J Gynecol Cancer, 2010, 20(6): 936
[10] Yamasaki T, Kurokawa F, Shirahashi H, et al. Percutaneous radiofrequency ablation therapy with combined angiography and computed tomography assistance for patients with hepatocellular carcinoma[J]. Cancer, 2001, 91(7): 1342
[11] 曾晖. 射频联合 TACE 对原发性肝癌近期疗效的影响[J]. 中国健康月刊: B, 2011, 30(3): 144
[12] 王能, 钱国军, 沈强, 等. 经皮肝穿刺射频治疗肝恶性肿瘤的严重并发症分析[J]. 中华肝胆外科杂志, 2011, 17(3): 186
 

相似文献/References:

备注/Memo

备注/Memo:
作者简介 孟令凯（1986-），男，医师，硕士在读，研究方向：普通外科；

通信作者：章志翔，E-mail：zhixiang63@sina.com。

更新日期/Last Update: 2014-03-31