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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

20卷

期数:

2014年01期

页码:

29-031

栏目:

临床医学

出版日期:

2014-01-20

文章信息/Info

Title:

Impact of numbers of embryos and prime embryo transfer on pregnancy outcome

文章编号:

1006-8147(2014)01-0029-03

作者:

黎小佩¹; 张云山²

(1.天津医科大学研究生院,天津 300070;2.天津市中心妇产科医院生殖医学中心,天津300052)

Author(s):

LI Xiao-pei¹;  ZHANG Yun-shan²

(1.Graduate School, Tianjin Medical University, Tianjin 300070, China; 2.Center for Reproductive Medicine, Tianjin Central Hospital of Obstetrics and Gynecology，Tianjin 300052,China)

关键词:

体外受精-胚胎移植; 年龄; 胚胎数目; 优质胚胎; 妊娠结局

Keywords:

in vitro fertilization-embryo transfer;  age;  numbers of embryo;  prime embryo;  pregnancy outcome

分类号:

R711.6

DOI:

-

文献标志码:

A

摘要:

 目的:探讨体外受精-胚胎移植(IVF-ET)周期中，移植胚胎数及移植优质胚胎数对妊娠结局的影响。方法:回顾性分析行辅助生殖 (IVF/ICSI)治疗并新鲜移植的病例共4 190个周期，根据患者年龄分为＜35岁组，35~37岁组和≥38岁组，分别统计各年龄段移植1、2、3个胚胎和移植0、1、2、3个优胚的临床妊娠率、单胎妊娠率、多胎妊娠率和异位妊娠率。结果:⑴＜35岁组中，移植1、2个胚胎的临床妊娠率无统计学差异，移植1、2个优胚者获得了相似的临床妊娠率，显著高于无优胚移植者；移植2个优胚者，多胎妊娠率显著高于移植1个优胚者。⑵35~37岁组，移植2个或3个胚胎的临床妊娠率无统计学差异，且明显高于移植1个胚胎者；移植1、2、3个优胚的临床妊娠率显著高于无优胚移植者，同时移植3个优胚者，其多胎妊娠率及异位妊娠率均显著增加。⑶在≥38岁组中，无论是移植2个或3个胚胎，还是2个或3个优胚，其临床妊娠率均显著高于移植1个胚胎及1个优胚者，且移植3个优胚者其多胎妊娠率及异位妊娠率也明显提高。结论:年龄＜35岁的患者和35~37岁的患者可以分别选择1个和2 个优质胚胎移植，年龄≥38岁的患者应尽量避免移植3个优质胚胎，以减少多胎妊娠及异位妊娠的发生。

Abstract:

 Objective: To explore the impact of numbers of embryos and prime embryos transfer at different ages on pregnancy outcome. Methods: Forty one thousand and ninety fresh cycles from infertile patients who underwent in vitro fertilization-embryo transfer (IVF-ET) were retrospectively analyzed. The patients were divided into group 1(younger than 35 years), group 2(between 35 and 37 years) and group 3(38 years and older). The pregnancy outcomes were compared and analyzed among the three groups. Results: ⑴In group 1, no statistically significant difference was found in clinical pregnancy rate. And the multiple pregnancy rate and ectopic pregnancy rate in patients who received two prime embryo transfer were higher than those who received one. ⑵In group 2, no statistically significant difference was found in clinical pregnancy rate whether two or three embryos transferred, and obviously higher than those who received one embryo transfer. The multiple pregnancy rate and ectopic pregnancy rate in patients who received three prime embryo transfer were obviously higher. ⑶In group 3, the clinical pregnancy rate was significantly lower than group 1 and group 2, and the multiple pregnancy rate and ectopic pregnancy rate in patients who received three prime embryo transfer were higher than those received one or two. Conclusion: One prime embryo transfer is advised for patients younger than 35 years, and one or two prime embryo transfer for the patients between 35~37 years. For the patients aged 38 and older, they should carefully select three prime embryos to reduce the risk of multiple pregnancy and ectopic pregnancy.

参考文献/References:

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备注/Memo

备注/Memo:

作者简介 黎小佩（1988-），女，硕士在读，研究方向：妇产科辅助生殖技术；
通信作者：张云山，E-mail:Peggylai@126.com。

常用功能

更新日期/Last Update: 2014-03-25