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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

20卷

期数:

2014年01期

页码:

25-028

栏目:

临床医学

出版日期:

2014-01-20

文章信息/Info

Title:

Relationship between non-HDL-C, remnant cholesterol and subclinical atherosclerosis of obese children

文章编号:

1006-8147(2014)01-0025-04

作者:

焦朝艳; 刘戈力; 鲍鹏丽; 魏 莹; 杨箐岩; 郑荣秀; 赵 菁

(天津医科大学总医院儿科, 天津 300052)

Author(s):

JIAO Chao-yan ; LIU Ge-li ; BAO Peng-li ; WEI Ying ; YANG Qing-yan ; ZHENG Rong-xiu ;  ZHAO Jing

(Department of Pediatrics, General Hospital, Tianjin Medical University, Tianjin 300052, China)

关键词:

儿童肥胖; 亚临床动脉粥样硬化; non-HDL-C; remnant cholesterol; 血浆致动脉粥样硬化指数; 颈动脉内膜-中层厚度

Keywords:

childhood obesity;  subclinical atherosclerosis;  non-HDL-C;  remnant cholesterol;  atherogenic index of plasma;  carotid intima-media thickness

分类号:

R541.4

DOI:

-

文献标志码:

A

摘要:

 目的:了解non-HDL-C和remnant cholesterol与肥胖儿童亚临床动脉粥样硬化（AS）的关系。方法:根据甘油三酯（TG）水平将65例肥胖儿童（肥胖组）分为I组（TG≥2.3 mmol/L）32例，II组（TG<2.3 mmol/L）33例，与肥胖组儿童性别年龄相匹配的正常体质量儿童30例为III组（对照组）。比较3组儿童血脂指标，对肥胖组各项血脂指标与血浆致动脉粥样硬化指数（AIP）进行相关性分析，肥胖患儿体质指数、血脂指标与颈动脉内径、内膜-中层厚度(c-IMT)、血流参数进行相关性分析。结果:I组、II组的TG、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、non-HDL-C、remnant cholesterol、AIP均较对照组升高，高密度脂蛋白胆固醇(HDL-C)较对照组降低，且I组的remnant cholesterol、AIP均较II组升高。肥胖组儿童 AIP与TG、non-HDL-C、remnant cholesterol呈正相关，与HDL-C呈负相关。37例行颈动脉超声检查的肥胖儿童的c-IMT较正常儿童的增厚。结论: non-HDL-C、remnant cholesterol在肥胖儿童亚临床AS中有重要作用，在肥胖儿童血脂异常的治疗中应关注non-HDL-C、remnant cholesterol的变化。

Abstract:

 Objective: To investigate the value of non-HDL-C and remnant cholesterol in the state of subclinical atherosclerosis for obese children. Methods: A total of 65 obese children were enrolled in this trial including 37 obese children who performed carotid ultrasound examination. According to the level of triglyceride (TG), these obese children were divided into two groups: group I (n =32, TG≥2.3 mmol/L) and group II ( n =33, TG<2.3 mmol/L). Thirty healthy children whose age and sex were matched served as the control group. Serum lipid parameters of the three groups were compared. The relationships between the lipid metabolic indices, non-HDL-C, remnant cholesterol and atherogenic index of plasma (AIP) in the obese group were analyzed. The relationships between all of the indices and the intima-media thickness（c-IMT）, inner diameter, peak flow of the carotid artery of the obese children who performed carotid ultrasound examination were also analyzed. Results: Triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-HDL-C, remnant cholesterol, AIP in the obese group(group I and group II) were significantly higher than that of the control group, but HDL-C of the obese group was lower than that of the control group. The levels of remnant cholesterol and AIP in group I were higher than that in group II. TG, non-HDL-C and remnant cholesterol were correlated with AIP of the obese group. The c-IMT of the obese children who performed carotid ultrasound examination was thicker than that of the normal children. Conclusion: Non-HDL-C and remnant cholesterol play an important role in the state of subclinical atherosclerosis for obese children. Non-HDL-C and remnant cholesterol should be taken into account in the lipid-lowering for obese children.

参考文献/References:

[ 1] Farwell W R, Sesso H D, Buring J E, et al. Non-high-density lipoprotein cholesterol versus low-density lipoprotein cholesterol as a risk for a first nonfatal Myocardial infarction [J]. Am J Cardiol, 2005, 96(8):129

[ 2] National Cholesterol Education Program(NCEP) Expert panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults( Adult Treatment PanelⅢ). Third Report of The National Cholesterol Education Program(NCEP) Expert panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults( Adult Treatment PanelⅢ) Final Report[J]. Circulation, 2002, 106(25):3143

[ 3] Varbo A, Benn M, Tybjærg-Hansen A, et al. Remnant cholesterol as a causal risk factor for ischemic heart disease[J]. Am J Coll Cardiol, 2013,61(4):427

[ 4] Matturri L, Ottaviani G, Lavezzi A M, et al. Early atherosclerotic lesions of the cardiac conduction system arteries in infants[ J] . Cardiovasc Pathol , 2004,13(5): 276

[ 5] Skilton M R, Evans N, Griffiths K A, et al. Aortic wall thickness in newborns with intrauterine growth restriction[ J] . Lancet, 2005,365(9469): 1484

[ 6] McGill H C Jr, McMahan C A, Herderick E E, et al. Origin of atherosclerosis in childhood and adolescence [ J] . Am J Clin Nutr, 2000, 72(5 Suppl): 1307S

[ 7] Chambless L E, Folsom A R, Davis V, et al. Risk factors for progression of common carotid atherosclerosis: the Atherosclerosis Risk in Communities Study, 1987-1998[J]. Am J Epidemiol, 2002,155(1): 38

[ 8] Li S, Chen W, Srinivasan S R, et a1. Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa Heart Study[J]. JAMA, 2003,290(17):2271

[ 9] 鲍鹏丽,刘戈力,杨箐岩,等. 儿童腹型肥胖与心血管代谢危险因素关系的研究[J].天津医科大学学报,2010,16(3):509

[10] 艾乙, 夏青. 正常儿童颈动脉双功能彩色多普勒检测值研究[J]. 中国儿童保健杂志,2004,12(1):20

[11] Lamarche B, Tchernof A, Moorjani S, et al. Small dense ow-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men：prospective results from the Quebec cardiovascular study[J]. Circulation, 1997, 95(1): 69

[12] Dobiasova M, Frohlich J. The plasma parameter Log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL))[J]. Clin Biochem, 2001, 34(7): 583

[13] Frost P H, Havel R J. Rationale for use of non-high-density lipoprotein cholesterol rather than low-density lipoprotein cholesterol as a tool for lipoprotein cholesterol screening and assessment of risk and therapy[J]. Am J Cardiol, 1998, 81 (4A) : 26B

[14] Frontini M G, Srinivasan S R, Xu J H, et al. Unity of non-high-density lipoprotein cholesterol versus other lipoprotein measures in detecting subclinical atherosclerosis in young adults (The Bogalusa Heart Study)[J]. Am J Cardiol, 2007, 100(1):64

[15] 李健斋,王抒,曾平.非高密度脂蛋白胆固醇用于评估及预测冠心病危险[J].中国心血管病杂志,2004,32(11):963

[16] Miller M, Ginsberg H N, Schaefer E J. Relative atherogenicity and predictive value of non-high-density lipoprotein cholesterol for coronary heart disease[J]. Am J Cardiol, 2008, 101(7):1003

[17] 陈联辉,朱伟芬,梁黎,等.非高密度脂蛋白胆固醇对肥胖儿童非脂性心血管疾病危险因素的预测作用[J].中国当代儿科杂志,2013,15(5):356

[18] Sachdeva A, Cannon C P, Deedwania P C, et al. Lipid levels in patients hospitalized with coronary artery disease: an analysis of 136,905 hospitalizations in Get With The Guidelines[J]. Am heart J, 2009, 157(1):111

[19] Libby P. The forgotten majority: unfinished business in cardiovascular risk reduction [J]. Am Coll Cardiol, 2005, 46(7):1 225

[20] Miller M, Stone N J, Ballantyne C, et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association [J]. Circulation, 2011, 123(20):2292

[21] Mamo J C, Proctor S D, Smith D. Retention of chylomicron remnants by arterial tissue; importance of an efficient clearance mechanism from plasma[J]. Atherosclerosis, 1998,141 (Suppl):S63

[22] Zilversmit D B. A proposal linking atherogenesis to the interaction of endothelial lipoprotein lipase with triglyceride-rich lipoproteins[J]. Circ Res, 1973, 33(6):633

相似文献/References:

备注/Memo

备注/Memo:

作者简介  焦朝艳（1987-），女，硕士在读，研究方向：儿科内分泌学；

通信作者：刘戈力，E-mail：liugeli2001@126.com。

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更新日期/Last Update: 2014-03-25