|本期目录/Table of Contents|

[1]宋明伟,姜 葵.质子泵抑制剂与小肠细菌过生长关系的研究[J].天津医科大学学报,2014,20(06):445-447.
　SONG Ming-wei,JIANG Kui.Relationship between the proton pump inhibitors and small intestinal bacterial overgrowth[J].Journal of Tianjin Medical University,2014,20(06):445-447.
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质子泵抑制剂与小肠细菌过生长关系的研究(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
20卷
期数:
2014年06期
页码:
445-447
栏目:
基础医学
出版日期:
2014-11-20

文章信息/Info

Title:
Relationship between the proton pump inhibitors and small intestinal bacterial overgrowth
文章编号:
1006-8147（2014）06-0445-03
作者:
宋明伟; 姜 葵
(天津医科大学总医院消化科 ,天津 300052)
Author(s):
SONG Ming-wei ;  JIANG Kui
(Department of Gastroenterology, General Hospital, Tianjin Medical University, Tianjin 300052, China)
关键词:
质子泵抑制剂; 乳果糖呼气H2试验; 小肠细菌过生长
Keywords:
proton pump inhibitors ; lactulose H2 breath test ;  small intestinal bacterial overgrowth
分类号:
R574
DOI:
-
文献标志码:
A
摘要:
目的：探讨质子泵抑制剂(PPI)的使用与小肠细菌过生长(SIBO)发生之间的关系。方法：采用前瞻性对照性研究收集30例服用低剂量PPI的患者、28例服用高剂量PPI的患者，20例健康志愿者作为对照，通过乳果糖呼吸H2试验连续观察SIBO的发生情况。结果：低剂量PPI组中SIBO阳性18例，阴性12例，高剂量PPI组阳性22例，阴性6例，对照组阳性1例，阴性19例，低剂量与高剂量PPI组分别与健康对照组比较差异有统计学意义(P<0.01)，高剂量PPI组与低剂量组比较差异有统计学意义(P<0.05)；两个服药组的SIBO阳性率随服药时间的增加而增加（P>0.05）。同一时间段，高剂量PPI组的SIBO阳性率明显高于低剂量PPI组（P>0.05）；两组PPI的使用时间与SIBO阳性率均存在正相关。结论：长期、大量使用PPI的患者可增加小肠细菌过生长的阳性率，可能进一步增加疾病发生的风险。
Abstract:
Objective: To explore the relationship between the proton pump inhibitors(PPI) and small intestinal bacterial overgrowth(SIBO). Methods: Thirty patients taking with low dose PPI, 28 patients with high dose PPI and 20 healthy volunteers were prospectively analysed by lactulose H2 breath test. Results: Eighteen SIBO positive and 12 negative cases in low dose PPI group, 22 SIBO positive and 6 negative cases in high dose PPI group, 1 SIBO positive and 19 negative cases in the volunteer group were observed. Significant difference was found between the two PPI groups and volunteer group(P<0.01), as well as between the low dose PPI group and the high dose PPI group(P<0.05); Longer duration of PPI therapy, was accompanied by increased SIBO positive rate (P>0.05). With the same duration of PPI use, the SIBO positive rate of high dose PPI group was significantly higher than low dose PPI group (P>0.05); a positive relationship was found between the SIBO positive rate and the length of time taking PPI. Conclusion: High dose of PPI in the long term could increase the SIBO positive rate, which could induce some diseases.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介 宋明伟(1985-),女,硕士在读,研究方向:消化系疾病; 
通信作者：姜葵, E-mail:j iangkui66@sohu.com。
更新日期/Last Update: 2014-12-02