|本期目录/Table of Contents|

[1]纪昕欣,马 莉,李文良.基于SEER数据库分析地理分布对髓母细胞瘤患者预后的影响[J].天津医科大学学报,2019,25(06):585-589.
　JI Xin-xin,MA Li,LI Wen-liang.Geographical distribution affects prognosis of patients with medulloblastoma: a SEER based study[J].Journal of Tianjin Medical University,2019,25(06):585-589.
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基于SEER数据库分析地理分布对髓母细胞瘤患者预后的影响(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25卷
期数:
2019年06期
页码:
585-589
栏目:
临床医学
出版日期:
2019-11-20

文章信息/Info

Title:
Geographical distribution affects prognosis of patients with medulloblastoma: a SEER based study
文章编号:
1006-8147(2019)06-0585-05
作者:
纪昕欣; 马 莉; 李文良
（天津医科大学肿瘤医院脑系肿瘤科，国家肿瘤临床医学研究中心，天津市“肿瘤防治”重点实验室，天津市恶性肿瘤临床医学研究中心，天津 300060）
Author(s):
JI Xin-xin;  MA Li;  LI Wen-liang
（Department of Brain Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China）
关键词:
髓母细胞瘤; 地理分布; 预后; SEER
Keywords:
medulloblastoma;  geographical distribution;  prognosis;  SEER
分类号:
R739.41
DOI:
-
文献标志码:
A
摘要:
目的：确定社会因素与髓母细胞瘤患者预后之间的关系。方法：通过获取SEER数据库中1973-2015年间确诊的髓母细胞瘤患者信息进行回顾性分析，利用χ2检验比较不同地区间肿瘤临床病理参数的差异，并使用Kaplan-Meier生存分析和Log-rank法分析髓母细胞瘤患者5年生存率。将Cox比例风险回归模型应用于单因素和多因素分析，并运用GraphPad Prism 6绘制生存曲线。结果：地理分布与髓母细胞瘤患者的预后显著相关。美国中西部地区的患者5年生存率（60.0%）低于东北地区（69.4%）、南部地区（70.6%）和西部地区（69.6%）。结论：地理分布可能在髓母细胞瘤恶性进展中起着重要作用，有利于提高对髓母细胞瘤患者的精准治疗。
Abstract:
Objective: The aim of this study was to identify the association between social factors and medulloblastoma patient prognosis. Methods:We retrospectively analyzed the information of patients with medulloblastoma diagnosed between 1973 and 2015 in the SEER（the Surveillance, Epidemiology, and End Results）database.The chi-square test was used to compare the difference of clinicopathological parameters of tumors between different regions.The 5-year survival rates of patients with medulloblastoma were analyzed by Kaplan-Meier survival analysis and Log-rank method. Cox proportional hazard regression model was applied to univariate and multivariate analysis,and GraphPad Prism 6 was used to draw survival curve. Results: Our results revealed that the geographical distribution was significantly associated with the prognosis of medulloblastoma and could be beneficial for the precise treatment of patients with medulloblastoma.medulloblastoma patients based on the SEER database. Patients from the Midwest region of the USA had a lower 5-year survival rate (60.0%) than those from the Northeast (69.4%), South (70.6%), and West (69.6%). Conclusion: geographical distribution may play an important role in the malignant progression of

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备注/Memo

备注/Memo:
基金项目 国家自然科学基金青年项目资助 (81702481)；天津市自然科学基金青年项目资助(15JCQNJC44800)
作者简介 纪昕欣（1990-），女，硕士在读，研究方向：脑肿瘤的诊断和治疗；通信作者：李文良，E-mail: liwenliang2338@163.com。
更新日期/Last Update: 2020-01-20