|本期目录/Table of Contents|

[1]孙春阳 综 述,于春水 审 校.肿瘤酸度响应高分子药物载体研究进展[J].天津医科大学学报,2019,25(02):176-179.
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肿瘤酸度响应高分子药物载体研究进展(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
25卷
期数:
2019年02期
页码:
176-179
栏目:
综述
出版日期:
2019-03-20

文章信息/Info

Title:
-
文章编号:
1006-8147(2019)02-0176-04
作者:
孙春阳 综 述; 于春水 审 校
（天津医科大学总医院医学影像科，天津市功能影像重点实验室，天津300052）
Author(s):
-
关键词:
肿瘤酸度; 纳米药物载体; 肿瘤治疗; 响应性高分子; 体内输送屏障
Keywords:
-
分类号:
R318.08
DOI:
-
文献标志码:
A
摘要:
高分子药物载体可以提高药物输送效率，改善药物分布，增强抗肿瘤疗效并降低毒副作用。然而，研究结果显示，现有载体的设计仍存在诸多瓶颈，如组织渗透、肿瘤细胞摄取和胞内药物释放等，限制了载体疗效的进一步提高。肿瘤基质和肿瘤细胞内的低pH环境是由于肿瘤细胞正常的生理活动造成的，在各种实体瘤中均有发现，以其为基础构建智能响应性高分子药物载体，能够克服系统给药多重屏障，解决载体系统的实际问题，为载体系统的临床转化提供新的思路。
Abstract:
-

参考文献/References:


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备注/Memo

备注/Memo:
基金项目 国家自然科学基金青年科学基金资助项目（51603150） 作者简介 孙春阳（1988-），男，讲师，博士，研究方向：高分子药物载体；通信作者：于春水，E-mail：705235440@qq.com。
更新日期/Last Update: 2019-04-25