|本期目录/Table of Contents|

[1]徐宝娟,王世玉,唐生安,等.中国广西涠洲岛海域海绵Callyspongia sp.的化学成分研究[J].天津医科大学学报,2018,24(06):489-491.
　XU Bao-juan,WANG Shi-yu,TANG Sheng-an,et al.Study on the chemical components of the marine sponge Callyspongia sp. collected from the Weizhou island in Guangxi[J].Journal of Tianjin Medical University,2018,24(06):489-491.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
24卷
期数:
2018年06期
页码:
489-491
栏目:
基础医学
出版日期:
2018-11-20

文章信息/Info

Title:
Study on the chemical components of the marine sponge Callyspongia sp. collected from the Weizhou island in Guangxi
作者:
徐宝娟1; 王世玉2; 唐生安2; 王 雪2
（1.天津医科大学第二医院药学部，天津 300211；2.天津医科大学药学院，天津市临床药物关键技术重点实验室，天津 300070）
Author(s):
XU Bao-juan1;  WANG Shi-yu2; TANG Sheng-an2; WANG Xue2
（1. Department of pharmacy, The Second Hospital, Tianjin Medical University, Tianjin 300211, China; 2. School of Pharmacy, Tianjin Medical University,Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), Tianjin 300070, China）
关键词:
Callyspongiasp; 色谱分离
Keywords:
marine sponge;  Callyspongiasp.;  chromatographic separation
分类号:
R914
DOI:
-
文献标志码:
A
摘要:
目的：对采自中国广西涠洲岛海域海绵Callyspongia sp.的化学成分进行分离和结构鉴定。方法：采用硅胶薄层色谱、柱色谱、凝胶渗透色谱LH-20，半制备HPLC等方法对采自中国广西涠洲岛海域海绵Callyspongia sp.的次生代谢产物进行化学分离，并通过核磁共振谱(1D、2D NMR)、质谱 (ESI - MS)等方法，确定化合物的结构。结果：共分离得到8个化合物，分别为牛磺酸（1）、乙酰牛磺酸（2）、N-甲基吡啶-2-羧酸盐（3）、zooanemonin（4）、N-丁基乙酰胺（5）、尿嘧啶（6）、3-甲基尿嘧啶（7）、苯甲酸（8）。结论：化合物1-5和7-8均为首次从该属海绵中分离得到。
Abstract:
Objective: To study the chemical constituents from the marine sponge Callyspongia sp. collected from the Weizhou island in Guangxi. Methods: Various chromatography techniques were performed for the isolation and purification of the MeOH extracts. Their structures were determined mainly by extensive 1D and 2D NMR, MS analysis. Results: The isolated 8 compounds were elucidated as follows: taurine (1),N-acetyltaurine(2),N-methylpyridine-2-carboxylic salt(3),zooanemonin(4), N-butylacetamide (5), uracil(6), 3-methyluracil (7), andbenzoic acid(8). Conclusion: Compounds1-5,7-8 have been isolated from the genus Callyspongia for the first time.

参考文献/References:


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备注/Memo

备注/Memo:
基金项目 国家自然科学基金资助项目（81102371）；天津市自然科学基金重点项目（16JCZDJC32600）；中国博士后基金资助项目（2016M591399）
作者简介 徐宝娟（1989-），女，药师，学士，研究方向：中药学；通信作者：王雪，E-mail:wangxue@tmu.edu.cn。
更新日期/Last Update: 2018-11-30