|本期目录/Table of Contents|

[1]张彩红,朱 泽.滨海新区婴幼儿血流感染病原菌分析[J].天津医科大学学报,2018,24(04):340-343.
 ZHANG Cai-hong,ZHU ze.Pathogenic bacteria in bloodstream infection in infants in Binhai New Area[J].Journal of Tianjin Medical University,2018,24(04):340-343.
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滨海新区婴幼儿血流感染病原菌分析(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
24卷
期数:
2018年04期
页码:
340-343
栏目:
出版日期:
2018-07-20

文章信息/Info

Title:
Pathogenic bacteria in bloodstream infection in infants in Binhai New Area
作者:
张彩红12朱 泽1
1. 天津医科大学病原生物学系, 天津300070;2.天津市第五中心医院检验科,天津 300450
Author(s):
ZHANG Cai-hong12 ZHU ze1
1. Department of Pathogen Biology, Tianjin Medical University, Tianjin 300070, China; 2. Department of Laboratory, The Fifth Central Hospital of Tianjin, Tianjin 300450, China
关键词:
婴幼儿血流感染病原菌阳性报警时间抗菌药物
Keywords:
infants bloodstream infection pathogenic bacteria time to positive antibacterial drugs
分类号:
R378
DOI:
-
文献标志码:
摘要:
目的:研究婴幼儿血流感染的病原菌组成及阳性报警时间,为血流感染的早期诊断与抗生素合理应用提供依据。方法:选取滨海新区疑似血流感染患儿943例,经血培养分析病原菌种类及对临床常用药物的敏感性。结果:非重复菌株共收集到91株,其中位居前3名的是22株凝固酶阴性葡萄球菌(CoNS)、14株大肠埃希菌和8株无乳链球菌。未分离到万古霉素、利奈唑胺和替加环素耐药的革兰氏阳性球菌,大肠埃希菌和肺炎克雷伯菌对头孢替坦、亚胺培南、哌拉西林/他唑巴坦、美洛培南和阿米卡星的敏感性为100%。阴沟肠杆菌的TTP[(8.96±2.24) h]最短,光滑假丝酵母菌的TTP[(44.4±16.59)h]最长。结论:滨海新区婴幼儿血流感染主要是革兰阳性菌,病原菌对常用的抗菌药物敏感性较高,临床医生应根据试验结果选择合理的抗菌药物。
Abstract:
Objective: To study the composition of pathogenic bacteria and the time to positive(TTP) of infants bloodstream infection and to provide basis for the early diagnosis of bloodstream infection and the appropriate application of antibiotics. Methods: Nine hundred and forty-three infants with suspected bloodstream infection were selected, and blood culture was used to analyze the types of pathogenic bacteria and the sensitivity to commonly used drugs. Results: A total of 91 non-repetitive strains were collected, of which 22 were coagulase-negative staphylococci, 14 strains of Escherichia coli and 8 strains of Streptococcus agalactiae; No vancomycin, linezolid and tigecycline-resistant gram-positive cocci were isolated. Escherichia coli and klebsiella pneumoniae were 100% sensitive to ceftiptin, imipenem, piperacillin/tazobactam, meropinam and amikacin. The TTP of enterobacter cloacae[(8.96+2.24)h] was the shortest, and the TTP of candida glabratas was the longest[(44.4+16.59) h]. Conclusion: In Binhai New Area, Gram-positive bacteria are the main pathogenic bacteria in infants with bloodstream infections. The pathogenic bacteria are highly sensitive to the common antibacterial drugs, and the clinical doctors should choose proper antimicrobial agents according to the test results.

参考文献/References:


[1] Weston E J,Pondo T,Lewis M M, et al. The burden of invasive early-onset neonatal sepsis in the United States, 2005–2008[J]. Pediatr Infect Dis J, 2011,30(11):937
[2] Dramowski A, Cotton M F, Rabie H, et al. Trends in paediatric bloodstream infections at a South African referral hospital[J]. BMC Pediatr, 2015,15:33
[3] Guzman A M, Sanchez T, Barra R. Quality indicators for blood culture: three years of monitoring at a university hospital in Chile[J]. Rev Chilena Infect , 2012, 29(4):406
[4] Claire E L, Christian R, Caroline C. Time to positivity of blood cultures in infants 0 to 90 days old presenting to emergency department: Is 36 hours enough[J]. J Pediatric Infect Dis Soc, 2017,6(1):28
[5] 徐月波,董琳,刘琳,等.儿童医院获得性血流感染的临床特征和病原学分析[J].中华传染病杂志,2013,31(4):221
[6] 尚红,王毓三,申子瑜,等.全国临床检验操作规程[M].第4版.北京:人民卫生出版社,2015:629-630
[7] 何玺玉,陈贤楠.儿童/新生儿血流感染的定义及诊断[J].实用儿科临床杂志,2009, 24(18):1385
[8] 涂松济,王宁玲,储金华,等.儿科住院患儿血流感染临床特点及病原学分析[J].中国小儿血液与肿瘤杂志,2013,18(4):173
[9] Ansari S, Nepal H P, Gautam R, et al. Neonatal septicemia in nepal: Early-onset versus late-onset[J]. Int J Pediatr,2015, 2015:379806
[10] 吴晓明,钟华敏,关小珊,等.婴幼儿血培养分离细菌及其耐药性分析[J].国际检验医学杂志,2016,37(5):591
[11] 张交生,董意妹,郑跃杰,等.不同年龄发热患儿血培养阳性菌株分布及其耐药性分析[J].中国实用儿科杂志,2016,(3):215
[12] Abdelhamid S M. Time to positivity and antibiotic sensitivity of neonatal blood cultures[J]. J Glob Infect Dis, 2017,9(3):102
[13] Aydin T T, Tanir G, Bayhan G, et al. Clinical and microbiological features of resistant gram-negative bloodstream infections in children[J]. J Infect Public Health, 2017,10(2):211
[14] 贾忠兰,毕福玲,张彩明.新生儿败血症病原菌分布及耐药性分析[J].中华医院感染学杂志,2017,27(1):197
[15] Ning Y, Hu R,Yao G, et al. Time to positivity of blood culture and its prognostic value in bloodstream infection[J]. Eur J Clin Microbiol Infect Dis, 2016, 35(4):619
[16] Vamsi S R, Bhat R Y, Lewis L E, et al. Time to positivity of blood cultures in neonates[J]. Pediatr Infect Dis J, 2014,33(2):212
[17] Wilson M L.Principles and procedures for blood cultures: Approved guideline[S]. Clinical and Laboratory Standards Institute, M47-A,2007:15
[18] Neves L, Marra A R, Camargo T Z,et al. Correlation between mass and volume of collected blood with positivity of blood cultures[J].BMC Res Notes,2015,8:383
[19] Kumar Y, Qunibi M, Neal T J, et al. Time to positivity of neonatal blood cultures[J]. Arch Dis Child Fetal Neonatal Ed, 2001, 85(3):F182

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2018-07-20