|本期目录/Table of Contents|

[1]杨宏伟,牛文彦.探讨uKIM-1、IL-6、T细胞亚群在脓毒症急性肾损伤中早期检测的意义[J].天津医科大学学报,2018,24(02):145-147,155.
 YANG Hong-wei,NIU Wen-yan.Value of measuring uKIM,IL-6 and T-cell subsets in sepsis patients with acute kidney injury[J].Journal of Tianjin Medical University,2018,24(02):145-147,155.
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探讨uKIM-1、IL-6、T细胞亚群在脓毒症急性肾损伤中早期检测的意义(PDF)
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
24卷
期数:
2018年02期
页码:
145-147,155
栏目:
出版日期:
2018-03-20

文章信息/Info

Title:
Value of measuring uKIM,IL-6 and T-cell subsets in sepsis patients with acute kidney injury
作者:
杨宏伟牛文彦
天津医科大学免疫学系,天津 300070
Author(s):
YANG Hong-wei NIU Wen-yan
Department of Immunology,Tianjin Medical University, Tianjin 300070, China
关键词:
脓毒症急性肾损伤IL-6T细胞亚群肾损伤分子-1
Keywords:
sepsisacute kidney injuryinterleukin-6T-cell subsetskidney injury molecule-1
分类号:
R631
DOI:
-
文献标志码:
A
摘要:
目的:研究尿肾损伤分子-1(uKIM-1)、血清肌酐(sCr)、白介素-6(IL-6)及T细胞亚群在脓毒症致急性肾损伤( AKI)中的临床应用价值。方法:选择 ICU脓毒症患者69 例,根据有无肾功能损害分为脓毒症急性肾损伤组(AKI组)、非肾损伤组(非AKI组),其中AKI组患者39例,非AKI组患者30例。选择同期门诊健康体检者30例作为对照组。测定研究对象入科0、6、24、48 h血清肌酐与uKIM浓度以及入科24 h血清IL-6、T细胞亚群浓度,根据24 h内最差临床指标计算急性生理和慢性健康计算(APACHEⅡ)评分;采用统计软件SPSS13.0进行统计学分析。结果:脓毒症AKI组患者sCr、uKIM-1和血清IL-6检测结果均明显高于脓毒症非AKI组(P均<0.05),与sCr诊断AKI时间相比,uKIM-1能更早地诊断脓毒症急性肾损伤,且IL-6、uKIM-1与APACHEⅡ评分呈正相关。AKI组与非AKI组患者,外周血CD3+T、CD4+T和CD8+T细胞及CD4+T/CD8+T均明显低于对照组,AKI组低于非AKI组,差异均有统计学意义(P均<0.05)。结论:uKIM-1、血清IL-6及T细胞亚群监测可用于评估脓毒症致急性肾损伤病情及预后,uKIM-1比sCr对脓毒症急性肾损伤有更好的诊断效能。
Abstract:
Objective: To analyze the relationship among the expression levels of kidney injury molecule-1(KIM-1),creatinine,interleukin-6,and T-cell subsets in patients with acute kidney injury(AKI) induced by sepsis. Methods: Sixty-nine patients with sepsis admitted to ICU were divided into non-AKI group(n =30) and AKI group(n =39). Thirsty healthy people were also enrolled as healthy control group. The serum creatinine,uKIM,IL-6,T-cell subsets and acute physiology and chronic health evaluation(APACHE II) score were compared between 2 group, and the correlations among them were analyzed . Results:The blood level of creatinine, KIM and IL-6 were significantly higher in AKI group than those in non-AKI group. In AKI group, the CD3+T, CD4+T, CD8+T and CD4+T/CD8+T were significantly lower than those in non-AKI group. The differences were significantly different between the patients in the two groups. Conclusion:The blood level of KIM and IL-6 and the changes of T-cell subsets could be used to evaluate the degree of the disease and its prognosis. uKIM is more affected than creatinine.

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备注/Memo

备注/Memo:
文章编号 1006-8147(2018)02-0145-03
作者简介 杨宏伟(1971-),女,主任技师,硕士在读,研究方向:免疫专业;E-mail:yanghongwei1971@sina.com。
更新日期/Last Update: 2018-03-20