|本期目录/Table of Contents|

[1]班新超,孙保存,谷彦军,等. CXCR4和CathepsinD在恶性纤维组织细胞瘤中的表达及意义[J].天津医科大学学报,2014,20(04):169.
 BAN Xin-chao,SUN Bao-cun,GU Yan-jun,et al.Expression of CXCR4 and CathepsinD in malignant fibrous histiocytoma and their biological significance[J].Journal of Tianjin Medical University,2014,20(04):169.
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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:
20卷
期数:
2014年04期
页码:
169
栏目:
出版日期:
2014-07-08

文章信息/Info

Title:
Expression of CXCR4 and CathepsinD in malignant fibrous histiocytoma and their biological significance
作者:
 班新超123 孙保存13谷彦军13 魏秀平13 娄丹13李庆选2 郑燕君1
(1.天津医科大学病理学教研室,天津 300070;2.天津市天津医院病理科,天津300060;3.天津医科大学附属肿瘤医院病理科,天津 300060 )
Author(s):
BAN Xin-chao123 SUN Bao-cun13 GU Yan-jun134 WEI Xiu-ping13 LOU Dan13 LI Qing-xuan2 ZHENG Yan-jun1
(1.Department of Pathology, Tianjin Medical University, Tianjin 30070, China; 2. Department of Pathology, Tianjin Hospital, Tianjin 300060, China; 3 .Department of Pathology, Cancer Institute and Hospital , Tianjin Medical University, Tianjin, 300060,China)
关键词:
恶性纤维组织细胞瘤转移CXCR4CathepsinD
Keywords:
-
分类号:
-
DOI:
-
文献标志码:
A
摘要:
目的:探讨CXCR4和组织蛋白酶D(CathepsinD)的表达与恶性纤维组织细胞瘤(MFH)转移及预后的关系。方法:选取存档的55例MFH组织标本,根据临床资料分为有转移组和无转移组,利用免疫组织化学染色检测两组原发灶中CXCR4和CathepsinD蛋白的表达情况,比较其过表达患者与低表达患者的中位生存期;利用Real-time PCR检测20例MFH有转移组和无转移组原发灶中CXCR4和CathepsinD的mRNA表达水平。结果:CXCR4和CathepsinD表达水平在转移组均显著高于无转移组(P<0.05);CXCR4过表达者的中位生存期均显著低于其低表达者(P<0.05);CathepsinD过表达者的中位生存期低于其低表达者,但差异无显著性(P>0.05)。结论:过表达CXCR4和CathepsinD与MFH的远处转移有关,CXCR4可作为MFH预后不良的参考指标。
Abstract:
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参考文献/References:

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备注/Memo

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更新日期/Last Update: 2014-06-06