«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

32卷

期数:

2026年03期

页码:

265-269

栏目:

临床医学

出版日期:

2026-05-20

文章信息/Info

Title:

Study on the preventive effect of detection and treatment of iron deficiency in early pregnancy on gesta-tional anemia

文章编号:

1006-8147（2026）03-0265-05

作者:

郑丽红¹; 2; 郭伟红¹; 杨迎¹; 何庆¹

1.天津医科大学总医院内分泌代谢科，天津300052;2.天津市北辰区大张庄镇社区卫生服务中心，天津300040

Author(s):

ZHENG Lihong¹; 2; GUO Weihong¹; YANG Ying¹; HE Qing¹

1.Department of Endocrinology and Metabolism， Tianjin Medical University General Hospital， Tianjin 300052， China;2.Community Health Service Center of Dazhangzhuang Town， Beichen District， Tianjin 300040， China

关键词:

妊娠期铁缺乏; 缺铁性贫血; 血清铁蛋白

Keywords:

iron deficiency during pregnancy;  iron deficiency anemia;  serum ferritin

分类号:

R556.3

DOI:

10.20135/j.issn.1006-8147.2026.03.0265

文献标志码:

A

摘要:

目的：回顾性研究妊娠早期铁缺乏的检测及治疗对于妊娠期贫血的预防效果及妊娠结局的影响。方法：选取2022年10月—2024年9月就诊于天津市北辰区大张庄镇社区卫生服务中心妇女保健科的孕妇，妊娠早期进行血清铁蛋白检测并接受铁缺乏治疗的100例孕妇作为观察组，妊娠早期未进行血清铁蛋白检测的100例孕妇作为对照组。收集两组孕妇的产前检查结果，比较两组孕妇妊娠期贫血患病率、妊娠各时期血红蛋白水平及妊娠不良结局情况。结果：对照组孕妇妊娠期贫血患病率为40%，观察组孕妇妊娠期贫血患病率为24%，显著低于对照组（χ2=5.882，P=0.015）。两组孕妇妊娠早期、中期血红蛋白水平无显著性差异（Z=-0.445、-1.017，均P>0.05）；与对照组相比，观察组孕妇妊娠晚期、临产前血红蛋白水平明显升高（Z=-3.986、-2.609，均P<0.05）。两组孕妇不良妊娠结局情况均无明显统计学差异（均P>0.05）。结论：妊娠早期检测血清铁蛋白并及时干预铁缺乏，能有效预防妊娠期贫血的发生，显著提升妊娠晚期血红蛋白水平，但是对妊娠不良结局无明显改善。

Abstract:

Objective： To retrospectively analyze the effect of detection and treatment of iron deficiency in the first trimester on the prevention of anemia during pregnancy and pregnancy outcomes. Methods： Pregnant women who visited the Maternal and Women′s Health Care of Community Health Service Center of Dazhangzhuang Town， Beichen District， Tianjin from October 2022 to September 2024 were selected. A total of 100 pregnant women who underwent serum ferritin testing and received timely treatment of iron defici-ency in the first trimester were selected as the observation group， and 100 pregnant women who did not undergo serum ferritin testing in the first trimester were selected as the control group. The prenatal examination results of the two groups of pregnant women were collected， and the prevalence of anemia during pregnancy， hemoglobin levels in each period of pregnancy and the incidence of ad-verse pregnancy outcomes were compared between the two groups. Results： The prevalence of anemia during pregnancy was 40% in the control group and 24% in the observation group， which was significantly lower than that in the control group（χ2=5.882， P=0.015）. There were no significant differences in hemoglobin levels between the two groups in the first and second trimester（Z=-0.445，-1.017， all P>0.05）. Compared with the control group， the hemoglobin levels of the observation group in the third trimester of pregnancy and before labor were significantly higher（Z=-3.986，-2.609， both P<0.05）. There were no significant differences in the incidence of adverse pregnancy outcomes between the two groups（all P>0.05）. Conclusions： Detection of serum ferritin in the first trimester and timely treatment of iron deficiency can effectively prevent anemia during pregnancy and significantly improve hemoglobin level in the third trimester， but there is no significant improvement in adverse pregnancy outcomes.

参考文献/References:

[1] 刘晓曦，扆运杰，冯羿凯，等.中国妊娠期贫血流行状况分析[J].中国生育健康杂志，2021，32（3）：210-215.
[2] 曾悦，何国琳.妊娠期预防性补铁的研究进展[J].现代妇产科进展， 2023， 32（6）： 458-460.
[3] 尹立娜，赵薇，胡焕青，等.2016-2020年中国八省份孕妇贫血患病状况及流行趋势分析[J].中华预防医学杂志，2023，57（5）：736-740.
[4] JUNG J， RAHMAN M M， RAHMAN M S， et al. Effects of hemoglobin levels during pregnancy on adverse maternal and infant outcomes： a systematic review and meta-analysis[J]. Ann N Y Acad Sci，2019 ，1450（1）：69-82.
[5] KEMPPINEN L， MATTILA M， EKHOLM E， et al. Gestational iron deficiency anemia is associated with preterm birth， fetal growth re-striction， and postpartum infections[J]. Perinat Med， 2020，49（4）：431-438.
[6] 黄凯坤，刘瑞霞，阴赪宏.妊娠期铁缺乏及缺铁性贫血的研究进展[J].国际妇产科学杂志，2022，49（3）：335-339.
[7] WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations [Internet][M]. Geneva： World Health Organization， 2020.
[8] GEORGIEFF M K. Iron deficiency in pregnancy[J]. Am J Obstet Gynecol， 2020， 223（4）：516-524.
[9] 荆晓燕.血清铁蛋白联合血红蛋白监测在妊娠期贫血预防中的应用价值分析[J].中国社区医师，2021，37（28）：100-101.
[10] CANTOR A， HOLMES R， BOUGATSOS C， et al. Screening and supplementation for iron deficiency and iron deficiency anemia dur-ing pregnancy： systematic review to update the U.S. Preventive Ser-vices Task Force recommendation[R]. Rockville（MD）： Agency for Healthcare Research and Quality（US）， 2024.
[11] CLARKE L， FROESSLER B， TANG C， et al. Iron optimisation in pregnancy： a haematology in obstetric and women′s health collabo-rative consensus statement[J]. Intern Med J， 2025，55（2）：300-307.
[12] SANTANDER BALLEST魱N S， GIM魪NEZ CAMPOS M I， BALLE-ST魱N BALLEST魱N J， et al. Is supplementation with micronutrients still necessary during pregnancy? A review [J]. Nutrients，2021，13 （9）：31-34.
[13] STOFFEL N U， ZEDER C， BRITTENHAM G M， et al. Iron ab-sorption from supplements is greater with alternate day than with consecutive day dosing in iron-deficient anemic women[J]. Haema-tologica， 2020，105（5）：1232-1239.
[14] 中华医学会血液学分会红细胞疾病（贫血）学组.铁缺乏症和缺铁性贫血诊治和预防的多学科专家共识（2022年版）[J].中华医学杂志， 2022， 102（41）：3246-3256.
[15] 中华医学会围产医学分会. 妊娠期铁缺乏和缺铁性贫血诊治指南[J].中华围产医学杂志，2014，17（7）：451-454.

相似文献/References:

备注/Memo

备注/Memo:

基金项目 国家自然科学基金青年科学基金（82400929）；天津市科技局重大专项（21ZXJBSY00060）
作者简介 郑丽红（1993-），女，主治医师，硕士在读，研究方向：内分泌与代谢病；通信作者：何庆，E-mail：hech69@163.com。
（2025-09-25收稿）

常用功能

更新日期/Last Update: 2026-05-25