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《天津医科大学学报》[ISSN:1006-8147/CN:12-1259/R]

卷:

20卷

期数:

2014年04期

页码:

286-288

栏目:

临床医学

出版日期:

2014-07-08

文章信息/Info

Title:

Correlation between hepatitis C virus genotypes and clinical index in Tianjin

文章编号:

1006-8147（2014）04-0286-03

作者:

金海涵¹;  林宝禄² ; 刘树业³

（1.天津医科大学三中心临床学院检验科，天津 300170；2.天津市滨海新区塘沽中心血站，天津 300456；3.天津市第三中心医院检验科；天津市人工细胞重点实验室，天津 300170）

Author(s):

JIN Hai-han¹; LIN Bao-lu²;  LIU Shu-ye³

(1. Department of Laboratory ,The Third Central Clinical College , Tianjin Medical University , Tianjin 300170, China; 2.Tianjin Binhai Tanggu Blood Station , Tianjin 300456 ,China; 3.The Third Central Clinical Hospital of Tianjin; Tianjin Key laboratory of artificial cell ,Tianjin 300170 , China)

关键词:

丙型肝炎病毒; 基因分型; 基因测序; 天津地区

Keywords:

Hepatitis C virus;  genotype;  gene sequencing; Tianjin region

分类号:

R575.1

DOI:

-

文献标志码:

A

摘要:

目的： 研究丙型肝炎病毒基因型，了解天津地区丙型肝炎的分布情况。方法： 收集252例丙型肝炎患者的血清标本，采用基因测序法进行HCV基因型的检测，并对基因型与其他临床指标进行分析。结果： 252例丙型肝炎患者分别感染1b、1a、1c、2a、2i、3a、3b、4a和6a共9种基因亚型，其中1b型占59.9%，其次是3a型，占12.7%。对1型、2型、3型和4型4种基因型进行肝功能、HCV RNA病毒载量比较，经单因素方差分析有明显统计学差异（P<0.05）；对HCV感染的不同肝病程度患者的基因型分布进行分析，无显著性差异（P>0.05）。结论： 天津地区丙型肝炎病毒感染以1b型为主，其次为3a型。HCV基因型与HCV RNA 病毒载量、肝脏损伤指标有明显统计学差异。

Abstract:

Objective ：To study the HCV genotype in chronic hepatitis C patients and explore the distribution of hepatitis C in Tianjin region. Methods： Serum specimens from 252 patients hepatitis C were collected for genotype by gene sequencing technique. Results：In the 252 specimens with HCV infection, nine gene genotypes were detected, including 1b（59.9%）,1a,1c,2a,2i,3a（12.7%）,3b,4a and 6a. Significant difference was observed between HCV genotypes and HCV RNA，liver function (P<0.05). No significant difference between HCV genotypes and various liver diseases distribution was found (P>0.05). Conclusion：HCV 1b is the most prevalent type in Tianjin, followed by type 3a. HCV genotypes are associated with HCV RNA level and liver function.

参考文献/References:

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相似文献/References:

备注/Memo

备注/Memo:

作者简介 金海涵（1979-），女，硕士在读，研究方向：临床检验诊断学 ;

通信作者：刘树业 ，E-mail：lshye@163.com。

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更新日期/Last Update: 2014-06-06